Glucose-6-Phosphate Dehydrogenase Status and Risk of Hemolysis in Plasmodium falciparum-Infected African Children Receiving Single-Dose Primaquine

Glucose-6-phosphate dehydrogenase (G6PD) enzyme function and genotype were determined in Ugandan children with uncomplicated falciparum malaria enrolled in a primaquine trial after exclusion of severe G6PD deficiency by fluorescent spot test. G6PD A− heterozygotes and hemizygotes/homozygotes experie...

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Autores principales: Eziefula, Alice C., Pett, Helmi, Grignard, Lynn, Opus, Salome, Kiggundu, Moses, Kamya, Moses R., Yeung, Shunmay, Staedke, Sarah G., Bousema, Teun, Drakeley, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2014
Materias:
Clinical Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136063/
https://www.ncbi.nlm.nih.gov/pubmed/24913169
http://dx.doi.org/10.1128/AAC.02889-14
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author Eziefula, Alice C.
Pett, Helmi
Grignard, Lynn
Opus, Salome
Kiggundu, Moses
Kamya, Moses R.
Yeung, Shunmay
Staedke, Sarah G.
Bousema, Teun
Drakeley, Chris
author_facet Eziefula, Alice C.
Pett, Helmi
Grignard, Lynn
Opus, Salome
Kiggundu, Moses
Kamya, Moses R.
Yeung, Shunmay
Staedke, Sarah G.
Bousema, Teun
Drakeley, Chris
author_sort Eziefula, Alice C.
collection PubMed
description Glucose-6-phosphate dehydrogenase (G6PD) enzyme function and genotype were determined in Ugandan children with uncomplicated falciparum malaria enrolled in a primaquine trial after exclusion of severe G6PD deficiency by fluorescent spot test. G6PD A− heterozygotes and hemizygotes/homozygotes experienced dose-dependent lower hemoglobin concentrations after treatment. No severe anemia was observed.
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spelling pubmed-41360632014-08-26 Glucose-6-Phosphate Dehydrogenase Status and Risk of Hemolysis in Plasmodium falciparum-Infected African Children Receiving Single-Dose Primaquine Eziefula, Alice C. Pett, Helmi Grignard, Lynn Opus, Salome Kiggundu, Moses Kamya, Moses R. Yeung, Shunmay Staedke, Sarah G. Bousema, Teun Drakeley, Chris Antimicrob Agents Chemother Clinical Therapeutics Glucose-6-phosphate dehydrogenase (G6PD) enzyme function and genotype were determined in Ugandan children with uncomplicated falciparum malaria enrolled in a primaquine trial after exclusion of severe G6PD deficiency by fluorescent spot test. G6PD A− heterozygotes and hemizygotes/homozygotes experienced dose-dependent lower hemoglobin concentrations after treatment. No severe anemia was observed. American Society for Microbiology 2014-08 /pmc/articles/PMC4136063/ /pubmed/24913169 http://dx.doi.org/10.1128/AAC.02889-14 Text en Copyright © 2014, Eziefula et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) .
spellingShingle Clinical Therapeutics
Eziefula, Alice C.
Pett, Helmi
Grignard, Lynn
Opus, Salome
Kiggundu, Moses
Kamya, Moses R.
Yeung, Shunmay
Staedke, Sarah G.
Bousema, Teun
Drakeley, Chris
Glucose-6-Phosphate Dehydrogenase Status and Risk of Hemolysis in Plasmodium falciparum-Infected African Children Receiving Single-Dose Primaquine
title Glucose-6-Phosphate Dehydrogenase Status and Risk of Hemolysis in Plasmodium falciparum-Infected African Children Receiving Single-Dose Primaquine
title_full Glucose-6-Phosphate Dehydrogenase Status and Risk of Hemolysis in Plasmodium falciparum-Infected African Children Receiving Single-Dose Primaquine
title_fullStr Glucose-6-Phosphate Dehydrogenase Status and Risk of Hemolysis in Plasmodium falciparum-Infected African Children Receiving Single-Dose Primaquine
title_full_unstemmed Glucose-6-Phosphate Dehydrogenase Status and Risk of Hemolysis in Plasmodium falciparum-Infected African Children Receiving Single-Dose Primaquine
title_short Glucose-6-Phosphate Dehydrogenase Status and Risk of Hemolysis in Plasmodium falciparum-Infected African Children Receiving Single-Dose Primaquine
title_sort glucose-6-phosphate dehydrogenase status and risk of hemolysis in plasmodium falciparum-infected african children receiving single-dose primaquine
topic Clinical Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136063/
https://www.ncbi.nlm.nih.gov/pubmed/24913169
http://dx.doi.org/10.1128/AAC.02889-14
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