Uukuniemi Phlebovirus Assembly and Secretion Leave a Functional Imprint on the Virion Glycome

Uukuniemi virus (UUKV) is a model system for investigating the genus Phlebovirus of the Bunyaviridae. We report the UUKV glycome, revealing differential processing of the Gn and Gc virion glycoproteins. Both glycoproteins display poly-N-acetyllactosamines, consistent with virion assembly in the medi...

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Autores principales: Crispin, Max, Harvey, David J., Bitto, David, Halldorsson, Steinar, Bonomelli, Camille, Edgeworth, Matthew, Scrivens, James H., Huiskonen, Juha T., Bowden, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2014
Materias:
Structure and Assembly
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136308/
https://www.ncbi.nlm.nih.gov/pubmed/24942574
http://dx.doi.org/10.1128/JVI.01662-14
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author Crispin, Max
Harvey, David J.
Bitto, David
Halldorsson, Steinar
Bonomelli, Camille
Edgeworth, Matthew
Scrivens, James H.
Huiskonen, Juha T.
Bowden, Thomas A.
author_facet Crispin, Max
Harvey, David J.
Bitto, David
Halldorsson, Steinar
Bonomelli, Camille
Edgeworth, Matthew
Scrivens, James H.
Huiskonen, Juha T.
Bowden, Thomas A.
author_sort Crispin, Max
collection PubMed
description Uukuniemi virus (UUKV) is a model system for investigating the genus Phlebovirus of the Bunyaviridae. We report the UUKV glycome, revealing differential processing of the Gn and Gc virion glycoproteins. Both glycoproteins display poly-N-acetyllactosamines, consistent with virion assembly in the medial Golgi apparatus, whereas oligomannose-type glycans required for DC-SIGN-dependent cellular attachment are predominant on Gc. Local virion structure and the route of viral egress from the cell leave a functional imprint on the phleboviral glycome.
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spelling pubmed-41363082014-09-01 Uukuniemi Phlebovirus Assembly and Secretion Leave a Functional Imprint on the Virion Glycome Crispin, Max Harvey, David J. Bitto, David Halldorsson, Steinar Bonomelli, Camille Edgeworth, Matthew Scrivens, James H. Huiskonen, Juha T. Bowden, Thomas A. J Virol Structure and Assembly Uukuniemi virus (UUKV) is a model system for investigating the genus Phlebovirus of the Bunyaviridae. We report the UUKV glycome, revealing differential processing of the Gn and Gc virion glycoproteins. Both glycoproteins display poly-N-acetyllactosamines, consistent with virion assembly in the medial Golgi apparatus, whereas oligomannose-type glycans required for DC-SIGN-dependent cellular attachment are predominant on Gc. Local virion structure and the route of viral egress from the cell leave a functional imprint on the phleboviral glycome. American Society for Microbiology 2014-09 /pmc/articles/PMC4136308/ /pubmed/24942574 http://dx.doi.org/10.1128/JVI.01662-14 Text en Copyright © 2014 Crispin et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) .
spellingShingle Structure and Assembly
Crispin, Max
Harvey, David J.
Bitto, David
Halldorsson, Steinar
Bonomelli, Camille
Edgeworth, Matthew
Scrivens, James H.
Huiskonen, Juha T.
Bowden, Thomas A.
Uukuniemi Phlebovirus Assembly and Secretion Leave a Functional Imprint on the Virion Glycome
title Uukuniemi Phlebovirus Assembly and Secretion Leave a Functional Imprint on the Virion Glycome
title_full Uukuniemi Phlebovirus Assembly and Secretion Leave a Functional Imprint on the Virion Glycome
title_fullStr Uukuniemi Phlebovirus Assembly and Secretion Leave a Functional Imprint on the Virion Glycome
title_full_unstemmed Uukuniemi Phlebovirus Assembly and Secretion Leave a Functional Imprint on the Virion Glycome
title_short Uukuniemi Phlebovirus Assembly and Secretion Leave a Functional Imprint on the Virion Glycome
title_sort uukuniemi phlebovirus assembly and secretion leave a functional imprint on the virion glycome
topic Structure and Assembly
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136308/
https://www.ncbi.nlm.nih.gov/pubmed/24942574
http://dx.doi.org/10.1128/JVI.01662-14
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