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A suppression hierarchy among competing motor programs drives sequential grooming in Drosophila
Motor sequences are formed through the serial execution of different movements, but how nervous systems implement this process remains largely unknown. We determined the organizational principles governing how dirty fruit flies groom their bodies with sequential movements. Using genetically targeted...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136539/ https://www.ncbi.nlm.nih.gov/pubmed/25139955 http://dx.doi.org/10.7554/eLife.02951 |
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author | Seeds, Andrew M Ravbar, Primoz Chung, Phuong Hampel, Stefanie Midgley, Frank M Mensh, Brett D Simpson, Julie H |
author_facet | Seeds, Andrew M Ravbar, Primoz Chung, Phuong Hampel, Stefanie Midgley, Frank M Mensh, Brett D Simpson, Julie H |
author_sort | Seeds, Andrew M |
collection | PubMed |
description | Motor sequences are formed through the serial execution of different movements, but how nervous systems implement this process remains largely unknown. We determined the organizational principles governing how dirty fruit flies groom their bodies with sequential movements. Using genetically targeted activation of neural subsets, we drove distinct motor programs that clean individual body parts. This enabled competition experiments revealing that the motor programs are organized into a suppression hierarchy; motor programs that occur first suppress those that occur later. Cleaning one body part reduces the sensory drive to its motor program, which relieves suppression of the next movement, allowing the grooming sequence to progress down the hierarchy. A model featuring independently evoked cleaning movements activated in parallel, but selected serially through hierarchical suppression, was successful in reproducing the grooming sequence. This provides the first example of an innate motor sequence implemented by the prevailing model for generating human action sequences. DOI: http://dx.doi.org/10.7554/eLife.02951.001 |
format | Online Article Text |
id | pubmed-4136539 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41365392014-08-22 A suppression hierarchy among competing motor programs drives sequential grooming in Drosophila Seeds, Andrew M Ravbar, Primoz Chung, Phuong Hampel, Stefanie Midgley, Frank M Mensh, Brett D Simpson, Julie H eLife Neuroscience Motor sequences are formed through the serial execution of different movements, but how nervous systems implement this process remains largely unknown. We determined the organizational principles governing how dirty fruit flies groom their bodies with sequential movements. Using genetically targeted activation of neural subsets, we drove distinct motor programs that clean individual body parts. This enabled competition experiments revealing that the motor programs are organized into a suppression hierarchy; motor programs that occur first suppress those that occur later. Cleaning one body part reduces the sensory drive to its motor program, which relieves suppression of the next movement, allowing the grooming sequence to progress down the hierarchy. A model featuring independently evoked cleaning movements activated in parallel, but selected serially through hierarchical suppression, was successful in reproducing the grooming sequence. This provides the first example of an innate motor sequence implemented by the prevailing model for generating human action sequences. DOI: http://dx.doi.org/10.7554/eLife.02951.001 eLife Sciences Publications, Ltd 2014-08-19 /pmc/articles/PMC4136539/ /pubmed/25139955 http://dx.doi.org/10.7554/eLife.02951 Text en Copyright © 2014, Seeds et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Seeds, Andrew M Ravbar, Primoz Chung, Phuong Hampel, Stefanie Midgley, Frank M Mensh, Brett D Simpson, Julie H A suppression hierarchy among competing motor programs drives sequential grooming in Drosophila |
title | A suppression hierarchy among competing motor programs drives sequential grooming in Drosophila |
title_full | A suppression hierarchy among competing motor programs drives sequential grooming in Drosophila |
title_fullStr | A suppression hierarchy among competing motor programs drives sequential grooming in Drosophila |
title_full_unstemmed | A suppression hierarchy among competing motor programs drives sequential grooming in Drosophila |
title_short | A suppression hierarchy among competing motor programs drives sequential grooming in Drosophila |
title_sort | suppression hierarchy among competing motor programs drives sequential grooming in drosophila |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136539/ https://www.ncbi.nlm.nih.gov/pubmed/25139955 http://dx.doi.org/10.7554/eLife.02951 |
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