Palladium-Catalyzed Regioselective Arylation of 1,1,3-Triaryl-2-azaallyl Anions with Aryl Chlorides

[Image: see text] A regioselective arylation of 1,1,3-triaryl-2-azaallyl anions with aryl chlorides is described. The palladium-NIXANTPHOS-based catalyst affords diarylmethylamine derivatives in good yield and without product isomerization. A gram scale sequential one-pot ketimine synthesis/arylatio...

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Autores principales: Li, Minyan, Berritt, Simon, Walsh, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136662/
https://www.ncbi.nlm.nih.gov/pubmed/25093713
http://dx.doi.org/10.1021/ol502043j
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author Li, Minyan
Berritt, Simon
Walsh, Patrick J.
author_facet Li, Minyan
Berritt, Simon
Walsh, Patrick J.
author_sort Li, Minyan
collection PubMed
description [Image: see text] A regioselective arylation of 1,1,3-triaryl-2-azaallyl anions with aryl chlorides is described. The palladium-NIXANTPHOS-based catalyst affords diarylmethylamine derivatives in good yield and without product isomerization. A gram scale sequential one-pot ketimine synthesis/arylation protocol was also developed.
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spelling pubmed-41366622015-08-05 Palladium-Catalyzed Regioselective Arylation of 1,1,3-Triaryl-2-azaallyl Anions with Aryl Chlorides Li, Minyan Berritt, Simon Walsh, Patrick J. Org Lett [Image: see text] A regioselective arylation of 1,1,3-triaryl-2-azaallyl anions with aryl chlorides is described. The palladium-NIXANTPHOS-based catalyst affords diarylmethylamine derivatives in good yield and without product isomerization. A gram scale sequential one-pot ketimine synthesis/arylation protocol was also developed. American Chemical Society 2014-08-05 2014-08-15 /pmc/articles/PMC4136662/ /pubmed/25093713 http://dx.doi.org/10.1021/ol502043j Text en Copyright © 2014 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html)
spellingShingle Li, Minyan
Berritt, Simon
Walsh, Patrick J.
Palladium-Catalyzed Regioselective Arylation of 1,1,3-Triaryl-2-azaallyl Anions with Aryl Chlorides
title Palladium-Catalyzed Regioselective Arylation of 1,1,3-Triaryl-2-azaallyl Anions with Aryl Chlorides
title_full Palladium-Catalyzed Regioselective Arylation of 1,1,3-Triaryl-2-azaallyl Anions with Aryl Chlorides
title_fullStr Palladium-Catalyzed Regioselective Arylation of 1,1,3-Triaryl-2-azaallyl Anions with Aryl Chlorides
title_full_unstemmed Palladium-Catalyzed Regioselective Arylation of 1,1,3-Triaryl-2-azaallyl Anions with Aryl Chlorides
title_short Palladium-Catalyzed Regioselective Arylation of 1,1,3-Triaryl-2-azaallyl Anions with Aryl Chlorides
title_sort palladium-catalyzed regioselective arylation of 1,1,3-triaryl-2-azaallyl anions with aryl chlorides
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136662/
https://www.ncbi.nlm.nih.gov/pubmed/25093713
http://dx.doi.org/10.1021/ol502043j
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AT berrittsimon palladiumcatalyzedregioselectivearylationof113triaryl2azaallylanionswitharylchlorides
AT walshpatrickj palladiumcatalyzedregioselectivearylationof113triaryl2azaallylanionswitharylchlorides

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