Mild Pd-Catalyzed Aminocarbonylation of (Hetero)Aryl Bromides with a Palladacycle Precatalyst

[Image: see text] A palladacyclic precatalyst is employed to cleanly generate a highly active XantPhos-ligated Pd-catalyst. Its use in low temperature aminocarbonylations of (hetero)aryl bromides provides access to a range of challenging products in good to excellent yields with low catalyst loading...

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Autores principales: Friis, Stig D., Skrydstrup, Troels, Buchwald, Stephen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136692/
https://www.ncbi.nlm.nih.gov/pubmed/25090373
http://dx.doi.org/10.1021/ol502014b
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author Friis, Stig D.
Skrydstrup, Troels
Buchwald, Stephen L.
author_facet Friis, Stig D.
Skrydstrup, Troels
Buchwald, Stephen L.
author_sort Friis, Stig D.
collection PubMed
description [Image: see text] A palladacyclic precatalyst is employed to cleanly generate a highly active XantPhos-ligated Pd-catalyst. Its use in low temperature aminocarbonylations of (hetero)aryl bromides provides access to a range of challenging products in good to excellent yields with low catalyst loading and only a slight excess of CO. Some products are unattainable by traditional carbonylative coupling.
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spelling pubmed-41366922015-08-04 Mild Pd-Catalyzed Aminocarbonylation of (Hetero)Aryl Bromides with a Palladacycle Precatalyst Friis, Stig D. Skrydstrup, Troels Buchwald, Stephen L. Org Lett [Image: see text] A palladacyclic precatalyst is employed to cleanly generate a highly active XantPhos-ligated Pd-catalyst. Its use in low temperature aminocarbonylations of (hetero)aryl bromides provides access to a range of challenging products in good to excellent yields with low catalyst loading and only a slight excess of CO. Some products are unattainable by traditional carbonylative coupling. American Chemical Society 2014-08-04 2014-08-15 /pmc/articles/PMC4136692/ /pubmed/25090373 http://dx.doi.org/10.1021/ol502014b Text en Copyright © 2014 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html)
spellingShingle Friis, Stig D.
Skrydstrup, Troels
Buchwald, Stephen L.
Mild Pd-Catalyzed Aminocarbonylation of (Hetero)Aryl Bromides with a Palladacycle Precatalyst
title Mild Pd-Catalyzed Aminocarbonylation of (Hetero)Aryl Bromides with a Palladacycle Precatalyst
title_full Mild Pd-Catalyzed Aminocarbonylation of (Hetero)Aryl Bromides with a Palladacycle Precatalyst
title_fullStr Mild Pd-Catalyzed Aminocarbonylation of (Hetero)Aryl Bromides with a Palladacycle Precatalyst
title_full_unstemmed Mild Pd-Catalyzed Aminocarbonylation of (Hetero)Aryl Bromides with a Palladacycle Precatalyst
title_short Mild Pd-Catalyzed Aminocarbonylation of (Hetero)Aryl Bromides with a Palladacycle Precatalyst
title_sort mild pd-catalyzed aminocarbonylation of (hetero)aryl bromides with a palladacycle precatalyst
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136692/
https://www.ncbi.nlm.nih.gov/pubmed/25090373
http://dx.doi.org/10.1021/ol502014b
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AT buchwaldstephenl mildpdcatalyzedaminocarbonylationofheteroarylbromideswithapalladacycleprecatalyst

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