Rapid Analysis of Protein Farnesyltransferase Substrate Specificity Using Peptide Libraries and Isoprenoid Diphosphate Analogues

[Image: see text] Protein farnesytransferase (PFTase) catalyzes the farnesylation of proteins with a carboxy-terminal tetrapeptide sequence denoted as a Ca(1)a(2)X box. To explore the specificity of this enzyme, an important therapeutic target, solid-phase peptide synthesis in concert with a peptide...

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Detalles Bibliográficos
Autores principales: Wang, Yen-Chih, Dozier, Jonathan K., Beese, Lorena S., Distefano, Mark D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136699/
https://www.ncbi.nlm.nih.gov/pubmed/24841702
http://dx.doi.org/10.1021/cb5002312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136699/
https://www.ncbi.nlm.nih.gov/pubmed/24841702
http://dx.doi.org/10.1021/cb5002312

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