Cargando…

Evaluation of Antimalarial Activity and Toxicity of a New Primaquine Prodrug

Plasmodium vivax is the most prevalent of the five species causing malaria in humans. The current available treatment for P. vivax malaria is limited and unsatisfactory due to at least two drawbacks: the undesirable side effects of primaquine (PQ) and drug resistance to chloroquine. Phenylalanine-al...

Descripción completa

Detalles Bibliográficos
Autores principales:	Davanço, Marcelo Gomes, Aguiar, Anna Caroline Campos, dos Santos, Leandro Alves, Padilha, Elias Carvalho, Campos, Michel Leandro, de Andrade, Cleverton Roberto, da Fonseca, Luiz Marcos, dos Santos, Jean Leandro, Chin, Chung Man, Krettli, Antoniana Ursine, Peccinini, Rosangela Gonçalves
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136845/ https://www.ncbi.nlm.nih.gov/pubmed/25133630 http://dx.doi.org/10.1371/journal.pone.0105217

Ejemplares similares

Synthesis, Characterization and Pharmacological Evaluation of 1-(2-Chloro-6-Fluorophenyl)-5-Methylindolin-2-One: A New Anti-Inflammatory Compound with Reduced Gastric Ulceration Properties
por: dos Santos, Jean Leandro, et al.
Publicado: (2010)

Antimalarial Activity and Mechanisms of Action of Two Novel 4-Aminoquinolines against Chloroquine-Resistant Parasites
por: Aguiar, Anna Caroline Campos, et al.
Publicado: (2012)

Pharmacological Evaluation and Preliminary Pharmacokinetics Studies of a New Diclofenac Prodrug without Gastric Ulceration Effect
por: dos Santos, Jean Leandro, et al.
Publicado: (2012)

Commercial drugs containing flavonoids are active in mice with malaria and in vitro against chloroquine-resistant Plasmodium falciparum
por: Penna-Coutinho, Julia, et al.
Publicado: (2018)

Antimalarial Activity of Potential Inhibitors of Plasmodium falciparum Lactate Dehydrogenase Enzyme Selected by Docking Studies
por: Penna-Coutinho, Julia, et al.
Publicado: (2011)

Mesoporous silica nanocarriers encapsulated antimalarials with high therapeutic performance
por: Amolegbe, Saliu Alao, et al.
Publicado: (2018)

Synthesis, ex Vivo and in Vitro Hydrolysis Study of an Indoline Derivative Designed as an Anti-Inflammatory with Reduced Gastric Ulceration Properties
por: Chung, Man Chin, et al.
Publicado: (2009)

Studies on Activities and Chemical Characterization of Medicinal Plants in Search for New Antimalarials: A Ten Year Review on Ethnopharmacology
por: Ceravolo, Isabela P., et al.
Publicado: (2021)

Primaquine-thiazolidinones block malaria transmission and development of the liver exoerythrocytic forms
por: Aguiar, Anna Caroline C., et al.
Publicado: (2017)

Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites
por: de Souza, Nicolli Bellotti, et al.
Publicado: (2015)

Aspidosperma (Apocynaceae) plant cytotoxicity and activity towards malaria parasites. Part II: experimental studies with Aspidosperma ramiflorum in vivo and in vitro
por: Aguiar, Anna CC, et al.
Publicado: (2015)

Aspidosperma (Apocynaceae) plant cytotoxicity and activity towards malaria parasites. Part I: Aspidosperma nitidum (Benth) used as a remedy to treat fever and malaria in the Amazon
por: Coutinho, Julia Penna, et al.
Publicado: (2013)

The Prodrug Approach: A Successful Tool for Improving Drug Solubility
por: Jornada, Daniela Hartmann, et al.
Publicado: (2015)

Chloroquine analogs as antimalarial candidates with potent in vitro and in vivo activity
por: Aguiar, Anna C.C., et al.
Publicado: (2018)

MEFAS, a hybrid of artesunate-mefloquine active against asexual stages of Plasmodium vivax in field isolates, inhibits malaria transmission
por: Penna-Coutinho, Julia, et al.
Publicado: (2021)

Coupling the Antimalarial Cell Penetrating Peptide TP10 to Classical Antimalarial Drugs Primaquine and Chloroquine Produces Strongly Hemolytic Conjugates
por: Aguiar, Luísa, et al.
Publicado: (2019)

5-Phenoxy Primaquine Analogs and the Tetraoxane Hybrid as Antimalarial Agents
por: Jansongsaeng, Somruedee, et al.
Publicado: (2021)

The Application of Prodrugs as a Tool to Enhance the Properties of Nucleoside Reverse Transcriptase Inhibitors
por: Fernandes, Lívia da Rocha, et al.
Publicado: (2023)

The antimalarial drug primaquine targets Fe–S cluster proteins and yeast respiratory growth
por: Lalève, Anaïs, et al.
Publicado: (2015)

Antimalarial activity of primaquine operates via a two-step biochemical relay
por: Camarda, Grazia, et al.
Publicado: (2019)

Enantiospecific pharmacokinetics and drug–drug interactions of primaquine and blood-stage antimalarial drugs
por: Chairat, Kalayanee, et al.
Publicado: (2018)

Computational Study on the Effect of Exocyclic Substituents on the Ionization Potential of Primaquine: Insights into the Design of Primaquine-Based Antimalarial Drugs with Less Methemoglobin Generation
por: Liu, Haining, et al.
Publicado: (2014)

Blood shizonticidal activities of phenazines and naphthoquinoidal compounds against Plasmodium falciparum in vitro and in mice malaria studies
por: de Souza, Nicolli Bellotti, et al.
Publicado: (2014)

Prodrugs for the Treatment of Neglected Diseases
por: Chung, Man Chin, et al.
Publicado: (2008)

Mobile robots
por: Coelho, Leandro dos Santos
Publicado: (2007)

MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis
por: Edwards, Rachel L., et al.
Publicado: (2017)

Curcumin Pharmacokinetic and Pharmacodynamic Evidences in Streptozotocin-Diabetic Rats Support the Antidiabetic Activity to Be via Metabolite(s)
por: Gutierres, Vânia Ortega, et al.
Publicado: (2015)

Anabolic-Androgenic Steroids and Exercise Training: Breaking the Myths and Dealing With Better Outcome in Sarcopenia
por: Falqueto, Hugo, et al.
Publicado: (2022)

Dementia and cognitive impairment in adults as sequels of HSV-1-related encephalitis: a review
por: Campos, Emille Magalhães Neves, et al.
Publicado: (2021)

Normalizing images is good to improve computer-assisted COVID-19 diagnosis
por: dos Santos, Claudio Filipi Gonçalves, et al.
Publicado: (2021)

Primaquine Diphosphate, a Known Antimalarial Drug, Blocks Vascular Leakage Acting Through Junction Stabilization
por: Noh, Minyoung, et al.
Publicado: (2021)

Anti-malarial activity of indole alkaloids isolated from Aspidosperma olivaceum
por: Chierrito, Talita PC, et al.
Publicado: (2014)

Oxygen Reduction Reaction on a Cu(II) Complex of 3,5-Diamino-1,2,4-triazole: A DFT Approach
por: Fonseca, Sarah, et al.
Publicado: (2020)

Special Issue “Drug Candidates for the Treatment of Infectious Diseases”
por: Man Chin, Chung, et al.
Publicado: (2023)

Plasmodium vivax and Plasmodium falciparum ex vivo susceptibility to anti-malarials and gene characterization in Rondônia, West Amazon, Brazil
por: Aguiar, Anna Caroline C, et al.
Publicado: (2014)

Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi
por: Andrade, Alice O., et al.
Publicado: (2023)

Advances in Drug Discovery of New Antitubercular Multidrug-Resistant Compounds †
por: Fernandes, Guilherme Felipe dos Santos, et al.
Publicado: (2017)

The effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatment
por: Sortica, Vinicius A, et al.
Publicado: (2016)

Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies
por: Adebayo, J. O., et al.
Publicado: (2013)

A Kinetic Study of the Main Guaco Metabolites Using Syrup Formulation and the Identification of an Alternative Route of Coumarin Metabolism in Humans
por: Gasparetto, João Cleverson, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_6uopias5jcvdcmitfh9dbi25c3