Cargando…
Coinfection with Human Herpesvirus 8 Is Associated with Persistent Inflammation and Immune Activation in Virologically Suppressed HIV-Infected Patients
OBJECTIVES: Infection with co-pathogens is one of the postulated factors contributing to persistent inflammation and non-AIDS events in virologically-suppressed HIV-infected patients. We aimed to investigate the relationship of human herpesvirus-8 (HHV-8), a vasculotropic virus implicated in the pat...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136871/ https://www.ncbi.nlm.nih.gov/pubmed/25133669 http://dx.doi.org/10.1371/journal.pone.0105442 |
_version_ | 1782331043479552000 |
---|---|
author | Masiá, Mar Robledano, Catalina Ortiz de la Tabla, Victoria Antequera, Pedro Lumbreras, Blanca Hernández, Ildefonso Gutiérrez, Félix |
author_facet | Masiá, Mar Robledano, Catalina Ortiz de la Tabla, Victoria Antequera, Pedro Lumbreras, Blanca Hernández, Ildefonso Gutiérrez, Félix |
author_sort | Masiá, Mar |
collection | PubMed |
description | OBJECTIVES: Infection with co-pathogens is one of the postulated factors contributing to persistent inflammation and non-AIDS events in virologically-suppressed HIV-infected patients. We aimed to investigate the relationship of human herpesvirus-8 (HHV-8), a vasculotropic virus implicated in the pathogenesis of Kaposi's sarcoma, with inflammation and subclinical atherosclerosis in HIV-infected patients. METHODS: Prospective study including virologically suppressed HIV-infected patients. Several blood biomarkers (highly-sensitive C-reactive protein [hsCRP], tumour necrosis factor-α, interleukin-6, monocyte chemoattractant protein-1, vascular cell adhesion molecule-1, intercellular cell adhesion molecule-1, malondialdehyde, plasminogen activator inhibitor [PAI-1], D-dimer, sCD14, sCD163, CD4/CD38/HLA-DR, and CD8/CD38/HLA-DR), serological tests for HHV-8 and the majority of herpesviruses, carotid intima-media thickness, and endothelial function through flow-mediated dilatation of the brachial artery were measured. RESULTS: A total of 136 patients were included, 34.6% of them infected with HHV-8. HHV-8-infected patients were more frequently co-infected with herpes simplex virus type 2 (HSV-2) (P<0.001), and less frequently with hepatitis C virus (HCV) (P = 0.045), and tended to be older (P = 0.086). HHV-8-infected patients had higher levels of hsCRP (median [interquartile range], 3.63 [1.32–7.54] vs 2.08 [0.89–4.11] mg/L, P = 0.009), CD4/CD38/HLA-DR (7.67% [4.10–11.86]% vs 3.86% [2.51–7.42]%, P = 0.035) and CD8/CD38/HLA-DR (8.02% [4.98–14.09]% vs 5.02% [3.66–6.96]%, P = 0.018). After adjustment for the traditional cardiovascular risk factors, HCV and HSV-2 infection, the associations remained significant: adjusted difference between HHV-8 positive and negative patients (95% confidence interval) for hsCRP, 74.19% (16.65–160.13)%; for CD4/CD38/HLA-DR, 89.65% (14.34–214.87)%; and for CD8/CD38/HLA-DR, 58.41% (12.30–123.22)%. Flow-mediated dilatation and total carotid intima-media thickness were not different according to HHV-8 serostatus. CONCLUSION: In virologically suppressed HIV-infected patients, coinfection with HHV-8 is associated with increased inflammation and immune activation. This might contribute to increase the risk of non-AIDS events, including accelerated atherosclerotic disease. |
format | Online Article Text |
id | pubmed-4136871 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-41368712014-08-20 Coinfection with Human Herpesvirus 8 Is Associated with Persistent Inflammation and Immune Activation in Virologically Suppressed HIV-Infected Patients Masiá, Mar Robledano, Catalina Ortiz de la Tabla, Victoria Antequera, Pedro Lumbreras, Blanca Hernández, Ildefonso Gutiérrez, Félix PLoS One Research Article OBJECTIVES: Infection with co-pathogens is one of the postulated factors contributing to persistent inflammation and non-AIDS events in virologically-suppressed HIV-infected patients. We aimed to investigate the relationship of human herpesvirus-8 (HHV-8), a vasculotropic virus implicated in the pathogenesis of Kaposi's sarcoma, with inflammation and subclinical atherosclerosis in HIV-infected patients. METHODS: Prospective study including virologically suppressed HIV-infected patients. Several blood biomarkers (highly-sensitive C-reactive protein [hsCRP], tumour necrosis factor-α, interleukin-6, monocyte chemoattractant protein-1, vascular cell adhesion molecule-1, intercellular cell adhesion molecule-1, malondialdehyde, plasminogen activator inhibitor [PAI-1], D-dimer, sCD14, sCD163, CD4/CD38/HLA-DR, and CD8/CD38/HLA-DR), serological tests for HHV-8 and the majority of herpesviruses, carotid intima-media thickness, and endothelial function through flow-mediated dilatation of the brachial artery were measured. RESULTS: A total of 136 patients were included, 34.6% of them infected with HHV-8. HHV-8-infected patients were more frequently co-infected with herpes simplex virus type 2 (HSV-2) (P<0.001), and less frequently with hepatitis C virus (HCV) (P = 0.045), and tended to be older (P = 0.086). HHV-8-infected patients had higher levels of hsCRP (median [interquartile range], 3.63 [1.32–7.54] vs 2.08 [0.89–4.11] mg/L, P = 0.009), CD4/CD38/HLA-DR (7.67% [4.10–11.86]% vs 3.86% [2.51–7.42]%, P = 0.035) and CD8/CD38/HLA-DR (8.02% [4.98–14.09]% vs 5.02% [3.66–6.96]%, P = 0.018). After adjustment for the traditional cardiovascular risk factors, HCV and HSV-2 infection, the associations remained significant: adjusted difference between HHV-8 positive and negative patients (95% confidence interval) for hsCRP, 74.19% (16.65–160.13)%; for CD4/CD38/HLA-DR, 89.65% (14.34–214.87)%; and for CD8/CD38/HLA-DR, 58.41% (12.30–123.22)%. Flow-mediated dilatation and total carotid intima-media thickness were not different according to HHV-8 serostatus. CONCLUSION: In virologically suppressed HIV-infected patients, coinfection with HHV-8 is associated with increased inflammation and immune activation. This might contribute to increase the risk of non-AIDS events, including accelerated atherosclerotic disease. Public Library of Science 2014-08-18 /pmc/articles/PMC4136871/ /pubmed/25133669 http://dx.doi.org/10.1371/journal.pone.0105442 Text en © 2014 Masiá et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Masiá, Mar Robledano, Catalina Ortiz de la Tabla, Victoria Antequera, Pedro Lumbreras, Blanca Hernández, Ildefonso Gutiérrez, Félix Coinfection with Human Herpesvirus 8 Is Associated with Persistent Inflammation and Immune Activation in Virologically Suppressed HIV-Infected Patients |
title | Coinfection with Human Herpesvirus 8 Is Associated with Persistent Inflammation and Immune Activation in Virologically Suppressed HIV-Infected Patients |
title_full | Coinfection with Human Herpesvirus 8 Is Associated with Persistent Inflammation and Immune Activation in Virologically Suppressed HIV-Infected Patients |
title_fullStr | Coinfection with Human Herpesvirus 8 Is Associated with Persistent Inflammation and Immune Activation in Virologically Suppressed HIV-Infected Patients |
title_full_unstemmed | Coinfection with Human Herpesvirus 8 Is Associated with Persistent Inflammation and Immune Activation in Virologically Suppressed HIV-Infected Patients |
title_short | Coinfection with Human Herpesvirus 8 Is Associated with Persistent Inflammation and Immune Activation in Virologically Suppressed HIV-Infected Patients |
title_sort | coinfection with human herpesvirus 8 is associated with persistent inflammation and immune activation in virologically suppressed hiv-infected patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136871/ https://www.ncbi.nlm.nih.gov/pubmed/25133669 http://dx.doi.org/10.1371/journal.pone.0105442 |
work_keys_str_mv | AT masiamar coinfectionwithhumanherpesvirus8isassociatedwithpersistentinflammationandimmuneactivationinvirologicallysuppressedhivinfectedpatients AT robledanocatalina coinfectionwithhumanherpesvirus8isassociatedwithpersistentinflammationandimmuneactivationinvirologicallysuppressedhivinfectedpatients AT ortizdelatablavictoria coinfectionwithhumanherpesvirus8isassociatedwithpersistentinflammationandimmuneactivationinvirologicallysuppressedhivinfectedpatients AT antequerapedro coinfectionwithhumanherpesvirus8isassociatedwithpersistentinflammationandimmuneactivationinvirologicallysuppressedhivinfectedpatients AT lumbrerasblanca coinfectionwithhumanherpesvirus8isassociatedwithpersistentinflammationandimmuneactivationinvirologicallysuppressedhivinfectedpatients AT hernandezildefonso coinfectionwithhumanherpesvirus8isassociatedwithpersistentinflammationandimmuneactivationinvirologicallysuppressedhivinfectedpatients AT gutierrezfelix coinfectionwithhumanherpesvirus8isassociatedwithpersistentinflammationandimmuneactivationinvirologicallysuppressedhivinfectedpatients |