Targeted Next-Generation Sequencing Reveals Novel USH2A Mutations Associated with Diverse Disease Phenotypes: Implications for Clinical and Molecular Diagnosis

USH2A mutations have been implicated in the disease etiology of several inherited diseases, including Usher syndrome type 2 (USH2), nonsyndromic retinitis pigmentosa (RP), and nonsyndromic deafness. The complex genetic and phenotypic spectrums relevant to USH2A defects make it difficult to manage pa...

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Detalles Bibliográficos
Autores principales: Chen, Xue, Sheng, Xunlun, Liu, Xiaoxing, Li, Huiping, Liu, Yani, Rong, Weining, Ha, Shaoping, Liu, Wenzhou, Kang, Xiaoli, Zhao, Kanxing, Zhao, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136877/
https://www.ncbi.nlm.nih.gov/pubmed/25133613
http://dx.doi.org/10.1371/journal.pone.0105439

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