Cargando…

Aberrant Methylation of Protocadherin 17 and its Clinical Significance in Patients with Prostate Cancer after Radical Prostatectomy

BACKGROUND: Aberrant methylation of protocadherin 17 (PCDH17) has been reported in several human cancers. However, the methylation status of PCDH17 in prostate cancer and its clinical significance remains unclear. The aim of this study was to investigate the methylation status of PCDH17 and its clin...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Ying-Li, Xie, Pei-Gen, Wang, Li, Ma, Jian-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136940/
https://www.ncbi.nlm.nih.gov/pubmed/25091018
http://dx.doi.org/10.12659/MSM.891247
_version_ 1782331052936658944
author Lin, Ying-Li
Xie, Pei-Gen
Wang, Li
Ma, Jian-Guo
author_facet Lin, Ying-Li
Xie, Pei-Gen
Wang, Li
Ma, Jian-Guo
author_sort Lin, Ying-Li
collection PubMed
description BACKGROUND: Aberrant methylation of protocadherin 17 (PCDH17) has been reported in several human cancers. However, the methylation status of PCDH17 in prostate cancer and its clinical significance remains unclear. The aim of this study was to investigate the methylation status of PCDH17 and its clinical significance in patients with prostate cancer after radical prostatectomy. MATERIAL/METHODS: The methylation status of PCDH17 in 152 prostate cancer tissues and 51 non-tumoral prostate tissues was examined by methylation-specific PCR (MSP). Then the association between PCDH17 methylation and clinicopathologic parameters was analyzed. Kaplan-Meier survival analysis, log-rank test and multivariate Cox proportional hazard model analysis were used to analyze the correlation between PCDH17 methylation and prognosis of patients with prostate cancer. RESULTS: Our data demonstrated that PCDH17 methylation occurred frequently in prostate cancer. PCDH17 methylation was significantly associated with higher pathological Gleason score (P=0.0315), advanced pathological stage (P=0.0260), higher level of preoperative PSA (P=0.0354), positive angiolymphatic invasion (P=0.0461), positive lymph node metastasis (P=0.0362), and biochemical recurrence (BCR) (P=0.0018). In addition, PCDH17 methylation was an independent predictor of poor biochemical recurrence-free (BCR-free) survival and overall survival for patients with prostate cancer. CONCLUSIONS: PCDH17 methylation is a frequent tumor-specific event in prostate cancer, and is significantly correlated with shorter BCR-free survival and overall survival of patients with prostate cancer after radical prostatectomy. PCDH17 methylation in tumor samples after radical prostatectomy may be used as an independent prognostic biomarker.
format Online
Article
Text
id pubmed-4136940
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher International Scientific Literature, Inc.
record_format MEDLINE/PubMed
spelling pubmed-41369402014-08-19 Aberrant Methylation of Protocadherin 17 and its Clinical Significance in Patients with Prostate Cancer after Radical Prostatectomy Lin, Ying-Li Xie, Pei-Gen Wang, Li Ma, Jian-Guo Med Sci Monit Lab/In Vitro Research BACKGROUND: Aberrant methylation of protocadherin 17 (PCDH17) has been reported in several human cancers. However, the methylation status of PCDH17 in prostate cancer and its clinical significance remains unclear. The aim of this study was to investigate the methylation status of PCDH17 and its clinical significance in patients with prostate cancer after radical prostatectomy. MATERIAL/METHODS: The methylation status of PCDH17 in 152 prostate cancer tissues and 51 non-tumoral prostate tissues was examined by methylation-specific PCR (MSP). Then the association between PCDH17 methylation and clinicopathologic parameters was analyzed. Kaplan-Meier survival analysis, log-rank test and multivariate Cox proportional hazard model analysis were used to analyze the correlation between PCDH17 methylation and prognosis of patients with prostate cancer. RESULTS: Our data demonstrated that PCDH17 methylation occurred frequently in prostate cancer. PCDH17 methylation was significantly associated with higher pathological Gleason score (P=0.0315), advanced pathological stage (P=0.0260), higher level of preoperative PSA (P=0.0354), positive angiolymphatic invasion (P=0.0461), positive lymph node metastasis (P=0.0362), and biochemical recurrence (BCR) (P=0.0018). In addition, PCDH17 methylation was an independent predictor of poor biochemical recurrence-free (BCR-free) survival and overall survival for patients with prostate cancer. CONCLUSIONS: PCDH17 methylation is a frequent tumor-specific event in prostate cancer, and is significantly correlated with shorter BCR-free survival and overall survival of patients with prostate cancer after radical prostatectomy. PCDH17 methylation in tumor samples after radical prostatectomy may be used as an independent prognostic biomarker. International Scientific Literature, Inc. 2014-08-05 /pmc/articles/PMC4136940/ /pubmed/25091018 http://dx.doi.org/10.12659/MSM.891247 Text en © Med Sci Monit, 2014 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
spellingShingle Lab/In Vitro Research
Lin, Ying-Li
Xie, Pei-Gen
Wang, Li
Ma, Jian-Guo
Aberrant Methylation of Protocadherin 17 and its Clinical Significance in Patients with Prostate Cancer after Radical Prostatectomy
title Aberrant Methylation of Protocadherin 17 and its Clinical Significance in Patients with Prostate Cancer after Radical Prostatectomy
title_full Aberrant Methylation of Protocadherin 17 and its Clinical Significance in Patients with Prostate Cancer after Radical Prostatectomy
title_fullStr Aberrant Methylation of Protocadherin 17 and its Clinical Significance in Patients with Prostate Cancer after Radical Prostatectomy
title_full_unstemmed Aberrant Methylation of Protocadherin 17 and its Clinical Significance in Patients with Prostate Cancer after Radical Prostatectomy
title_short Aberrant Methylation of Protocadherin 17 and its Clinical Significance in Patients with Prostate Cancer after Radical Prostatectomy
title_sort aberrant methylation of protocadherin 17 and its clinical significance in patients with prostate cancer after radical prostatectomy
topic Lab/In Vitro Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136940/
https://www.ncbi.nlm.nih.gov/pubmed/25091018
http://dx.doi.org/10.12659/MSM.891247
work_keys_str_mv AT linyingli aberrantmethylationofprotocadherin17anditsclinicalsignificanceinpatientswithprostatecancerafterradicalprostatectomy
AT xiepeigen aberrantmethylationofprotocadherin17anditsclinicalsignificanceinpatientswithprostatecancerafterradicalprostatectomy
AT wangli aberrantmethylationofprotocadherin17anditsclinicalsignificanceinpatientswithprostatecancerafterradicalprostatectomy
AT majianguo aberrantmethylationofprotocadherin17anditsclinicalsignificanceinpatientswithprostatecancerafterradicalprostatectomy