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Increased methylation of the MOR gene proximal promoter in primary sensory neurons plays a crucial role in the decreased analgesic effect of opioids in neuropathic pain

BACKGROUND: The analgesic potency of opioids is reduced in neuropathic pain. However, the molecular mechanism is not well understood. RESULTS: The present study demonstrated that increased methylation of the Mu opioid receptor (MOR) gene proximal promoter (PP) in dorsal root ganglion (DRG) plays a c...

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Detalles Bibliográficos
Autores principales:	Zhou, Xue-Long, Yu, Li-Na, Wang, Yin, Tang, Li-Hui, Peng, Yu-Nan, Cao, Jun-Li, Yan, Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137045/ https://www.ncbi.nlm.nih.gov/pubmed/25118039 http://dx.doi.org/10.1186/1744-8069-10-51

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