The nebulin repeat protein Lasp regulates I-band architecture and filament spacing in myofibrils

Mutations in nebulin, a giant muscle protein with 185 actin-binding nebulin repeats, are the major cause of nemaline myopathy in humans. Nebulin sets actin thin filament length in sarcomeres, potentially by stabilizing thin filaments in the I-band, where nebulin and thin filaments coalign. However,...

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Detalles Bibliográficos
Autores principales: Fernandes, Isabelle, Schöck, Frieder
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137052/
https://www.ncbi.nlm.nih.gov/pubmed/25113030
http://dx.doi.org/10.1083/jcb.201401094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137052/
https://www.ncbi.nlm.nih.gov/pubmed/25113030
http://dx.doi.org/10.1083/jcb.201401094

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