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The nebulin repeat protein Lasp regulates I-band architecture and filament spacing in myofibrils
Mutations in nebulin, a giant muscle protein with 185 actin-binding nebulin repeats, are the major cause of nemaline myopathy in humans. Nebulin sets actin thin filament length in sarcomeres, potentially by stabilizing thin filaments in the I-band, where nebulin and thin filaments coalign. However,...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Rockefeller University Press
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137052/ https://www.ncbi.nlm.nih.gov/pubmed/25113030 http://dx.doi.org/10.1083/jcb.201401094 |