A new piece in the kinetochore jigsaw puzzle

In eukaryotic cell division, the kinetochore mediates chromosome attachment to spindle microtubules and acts as a scaffold for signaling pathways, ensuring the accuracy of chromosome segregation. The architecture of the kinetochore underlies its function in mitosis. In this issue, Hornung et al. (20...

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Detalles Bibliográficos
Autores principales: Corbett, Kevin D., Desai, Arshad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137055/
https://www.ncbi.nlm.nih.gov/pubmed/25135931
http://dx.doi.org/10.1083/jcb.201407048
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author Corbett, Kevin D.
Desai, Arshad
author_facet Corbett, Kevin D.
Desai, Arshad
author_sort Corbett, Kevin D.
collection PubMed
description In eukaryotic cell division, the kinetochore mediates chromosome attachment to spindle microtubules and acts as a scaffold for signaling pathways, ensuring the accuracy of chromosome segregation. The architecture of the kinetochore underlies its function in mitosis. In this issue, Hornung et al. (2014. J. Cell Biol. http://dx.doi.org/201403081) identify an unexpected linkage between the inner and outer regions of the kinetochore in budding yeast that suggests a new model for the construction of this interface.
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spelling pubmed-41370552015-02-18 A new piece in the kinetochore jigsaw puzzle Corbett, Kevin D. Desai, Arshad J Cell Biol Reviews In eukaryotic cell division, the kinetochore mediates chromosome attachment to spindle microtubules and acts as a scaffold for signaling pathways, ensuring the accuracy of chromosome segregation. The architecture of the kinetochore underlies its function in mitosis. In this issue, Hornung et al. (2014. J. Cell Biol. http://dx.doi.org/201403081) identify an unexpected linkage between the inner and outer regions of the kinetochore in budding yeast that suggests a new model for the construction of this interface. The Rockefeller University Press 2014-08-18 /pmc/articles/PMC4137055/ /pubmed/25135931 http://dx.doi.org/10.1083/jcb.201407048 Text en © 2014 Corbett and Desai This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Corbett, Kevin D.
Desai, Arshad
A new piece in the kinetochore jigsaw puzzle
title A new piece in the kinetochore jigsaw puzzle
title_full A new piece in the kinetochore jigsaw puzzle
title_fullStr A new piece in the kinetochore jigsaw puzzle
title_full_unstemmed A new piece in the kinetochore jigsaw puzzle
title_short A new piece in the kinetochore jigsaw puzzle
title_sort new piece in the kinetochore jigsaw puzzle
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137055/
https://www.ncbi.nlm.nih.gov/pubmed/25135931
http://dx.doi.org/10.1083/jcb.201407048
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