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Modulation of the unfolded protein response by the human hepatitis B virus

During productive viral infection the host cell is confronted with synthesis of a vast amount of viral proteins which must be folded, quality controlled, assembled and secreted, perturbing the normal function of the endoplasmic reticulum (ER). To counteract the ER stress, cells activate specific sig...

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Autores principales: Lazar, Catalin, Uta, Mihaela, Branza-Nichita, Norica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137222/
https://www.ncbi.nlm.nih.gov/pubmed/25191311
http://dx.doi.org/10.3389/fmicb.2014.00433
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author Lazar, Catalin
Uta, Mihaela
Branza-Nichita, Norica
author_facet Lazar, Catalin
Uta, Mihaela
Branza-Nichita, Norica
author_sort Lazar, Catalin
collection PubMed
description During productive viral infection the host cell is confronted with synthesis of a vast amount of viral proteins which must be folded, quality controlled, assembled and secreted, perturbing the normal function of the endoplasmic reticulum (ER). To counteract the ER stress, cells activate specific signaling pathways, designated as the unfolded proteins response (UPR), which essentially increase their folding capacity, arrest protein translation, and degrade the excess of misfolded proteins. This cellular defense mechanism may, in turn, affect significantly the virus life-cycle. This review highlights the current understanding of the mechanisms of the ER stress activation by Human Hepatitis B virus (HBV), a deadly pathogen affecting more than 350 million people worldwide. Further discussion addresses the latest discoveries regarding the adaptive strategies developed by HBV to manipulate the UPR for its own benefits, the controversies in the field and future perspectives.
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spelling pubmed-41372222014-09-04 Modulation of the unfolded protein response by the human hepatitis B virus Lazar, Catalin Uta, Mihaela Branza-Nichita, Norica Front Microbiol Microbiology During productive viral infection the host cell is confronted with synthesis of a vast amount of viral proteins which must be folded, quality controlled, assembled and secreted, perturbing the normal function of the endoplasmic reticulum (ER). To counteract the ER stress, cells activate specific signaling pathways, designated as the unfolded proteins response (UPR), which essentially increase their folding capacity, arrest protein translation, and degrade the excess of misfolded proteins. This cellular defense mechanism may, in turn, affect significantly the virus life-cycle. This review highlights the current understanding of the mechanisms of the ER stress activation by Human Hepatitis B virus (HBV), a deadly pathogen affecting more than 350 million people worldwide. Further discussion addresses the latest discoveries regarding the adaptive strategies developed by HBV to manipulate the UPR for its own benefits, the controversies in the field and future perspectives. Frontiers Media S.A. 2014-08-19 /pmc/articles/PMC4137222/ /pubmed/25191311 http://dx.doi.org/10.3389/fmicb.2014.00433 Text en Copyright © 2014 Lazar, Uta and Branza-Nichita. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Lazar, Catalin
Uta, Mihaela
Branza-Nichita, Norica
Modulation of the unfolded protein response by the human hepatitis B virus
title Modulation of the unfolded protein response by the human hepatitis B virus
title_full Modulation of the unfolded protein response by the human hepatitis B virus
title_fullStr Modulation of the unfolded protein response by the human hepatitis B virus
title_full_unstemmed Modulation of the unfolded protein response by the human hepatitis B virus
title_short Modulation of the unfolded protein response by the human hepatitis B virus
title_sort modulation of the unfolded protein response by the human hepatitis b virus
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137222/
https://www.ncbi.nlm.nih.gov/pubmed/25191311
http://dx.doi.org/10.3389/fmicb.2014.00433
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