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The Clinicopathological Significance of MicroRNA-155 in Breast Cancer: A Meta-Analysis

Objective. Previous studies demonstrated that the associations between expression level of microRNA-155 (miR-155) and clinicopathological significance of breast cancer remained inconsistent. Therefore, we performed a meta-analysis based on eligible studies to summarize the possible associations. Met...

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Detalles Bibliográficos
Autores principales: Zeng, Hui, Fang, Cheng, Nam, Seungyoon, Cai, Qing, Long, Xinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137503/
https://www.ncbi.nlm.nih.gov/pubmed/25157366
http://dx.doi.org/10.1155/2014/724209
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author Zeng, Hui
Fang, Cheng
Nam, Seungyoon
Cai, Qing
Long, Xinghua
author_facet Zeng, Hui
Fang, Cheng
Nam, Seungyoon
Cai, Qing
Long, Xinghua
author_sort Zeng, Hui
collection PubMed
description Objective. Previous studies demonstrated that the associations between expression level of microRNA-155 (miR-155) and clinicopathological significance of breast cancer remained inconsistent. Therefore, we performed a meta-analysis based on eligible studies to summarize the possible associations. Methods. We identified eligible studies published up to May 2014 by a comprehensive search of PubMed, EMBASE, CNKI, and VIP databases. The analysis was performed with RevMan. 5.0 software. Results. A total of 15 studies were included. The results of meta-analysis showed that miR-155 was positively correlated with breast cancer with standardized mean difference (SMD) = 1.22. Elevated miR-155 was found in Her-2 positive or lymph node metastasis positive, or p53 mutant type breast cancer. But the result showed to be insignificant in TNM comparison. With respect to estrogen receptor alpha (ER) and progesterone receptor (PR) status, both of them showed significant associations with SMD = −1.2 and −1.85, respectively. Conclusion. MiR-155 detection might have a diagnostic value in breast cancer patients. It might be used as an auxiliary biomarker for different clinicopathological breast cancer.
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spelling pubmed-41375032014-08-25 The Clinicopathological Significance of MicroRNA-155 in Breast Cancer: A Meta-Analysis Zeng, Hui Fang, Cheng Nam, Seungyoon Cai, Qing Long, Xinghua Biomed Res Int Research Article Objective. Previous studies demonstrated that the associations between expression level of microRNA-155 (miR-155) and clinicopathological significance of breast cancer remained inconsistent. Therefore, we performed a meta-analysis based on eligible studies to summarize the possible associations. Methods. We identified eligible studies published up to May 2014 by a comprehensive search of PubMed, EMBASE, CNKI, and VIP databases. The analysis was performed with RevMan. 5.0 software. Results. A total of 15 studies were included. The results of meta-analysis showed that miR-155 was positively correlated with breast cancer with standardized mean difference (SMD) = 1.22. Elevated miR-155 was found in Her-2 positive or lymph node metastasis positive, or p53 mutant type breast cancer. But the result showed to be insignificant in TNM comparison. With respect to estrogen receptor alpha (ER) and progesterone receptor (PR) status, both of them showed significant associations with SMD = −1.2 and −1.85, respectively. Conclusion. MiR-155 detection might have a diagnostic value in breast cancer patients. It might be used as an auxiliary biomarker for different clinicopathological breast cancer. Hindawi Publishing Corporation 2014 2014-08-03 /pmc/articles/PMC4137503/ /pubmed/25157366 http://dx.doi.org/10.1155/2014/724209 Text en Copyright © 2014 Hui Zeng et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zeng, Hui
Fang, Cheng
Nam, Seungyoon
Cai, Qing
Long, Xinghua
The Clinicopathological Significance of MicroRNA-155 in Breast Cancer: A Meta-Analysis
title The Clinicopathological Significance of MicroRNA-155 in Breast Cancer: A Meta-Analysis
title_full The Clinicopathological Significance of MicroRNA-155 in Breast Cancer: A Meta-Analysis
title_fullStr The Clinicopathological Significance of MicroRNA-155 in Breast Cancer: A Meta-Analysis
title_full_unstemmed The Clinicopathological Significance of MicroRNA-155 in Breast Cancer: A Meta-Analysis
title_short The Clinicopathological Significance of MicroRNA-155 in Breast Cancer: A Meta-Analysis
title_sort clinicopathological significance of microrna-155 in breast cancer: a meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137503/
https://www.ncbi.nlm.nih.gov/pubmed/25157366
http://dx.doi.org/10.1155/2014/724209
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