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Reconstruction of Cochlea Based on Micro-CT and Histological Images of the Human Inner Ear

The study of the normal function and pathology of the inner ear has unique difficulties as it is inaccessible during life and, so, conventional techniques of pathologic studies such as biopsy and surgical excision are not feasible, without further impairing function. Mathematical modelling is theref...

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Autores principales: Bellos, Christos, Rigas, George, Spiridon, Ioannis F., Bibas, Athanasios, Iliopoulou, Dimitra, Böhnke, Frank, Koutsouris, Dimitrios, Fotiadis, Dimitrios I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137506/
https://www.ncbi.nlm.nih.gov/pubmed/25157360
http://dx.doi.org/10.1155/2014/485783
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author Bellos, Christos
Rigas, George
Spiridon, Ioannis F.
Bibas, Athanasios
Iliopoulou, Dimitra
Böhnke, Frank
Koutsouris, Dimitrios
Fotiadis, Dimitrios I.
author_facet Bellos, Christos
Rigas, George
Spiridon, Ioannis F.
Bibas, Athanasios
Iliopoulou, Dimitra
Böhnke, Frank
Koutsouris, Dimitrios
Fotiadis, Dimitrios I.
author_sort Bellos, Christos
collection PubMed
description The study of the normal function and pathology of the inner ear has unique difficulties as it is inaccessible during life and, so, conventional techniques of pathologic studies such as biopsy and surgical excision are not feasible, without further impairing function. Mathematical modelling is therefore particularly attractive as a tool in researching the cochlea and its pathology. The first step towards efficient mathematical modelling is the reconstruction of an accurate three dimensional (3D) model of the cochlea that will be presented in this paper. The high quality of the histological images is being exploited in order to extract several sections of the cochlea that are not visible on the micro-CT (mCT) images (i.e., scala media, spiral ligament, and organ of Corti) as well as other important sections (i.e., basilar membrane, Reissner membrane, scala vestibule, and scala tympani). The reconstructed model is being projected in the centerline of the coiled cochlea, extracted from mCT images, and represented in the 3D space. The reconstruction activities are part of the SIFEM project, which will result in the delivery of an infrastructure, semantically interlinking various tools and libraries (i.e., segmentation, reconstruction, and visualization tools) with the clinical knowledge, which is represented by existing data, towards the delivery of a robust multiscale model of the inner ear.
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spelling pubmed-41375062014-08-25 Reconstruction of Cochlea Based on Micro-CT and Histological Images of the Human Inner Ear Bellos, Christos Rigas, George Spiridon, Ioannis F. Bibas, Athanasios Iliopoulou, Dimitra Böhnke, Frank Koutsouris, Dimitrios Fotiadis, Dimitrios I. Biomed Res Int Research Article The study of the normal function and pathology of the inner ear has unique difficulties as it is inaccessible during life and, so, conventional techniques of pathologic studies such as biopsy and surgical excision are not feasible, without further impairing function. Mathematical modelling is therefore particularly attractive as a tool in researching the cochlea and its pathology. The first step towards efficient mathematical modelling is the reconstruction of an accurate three dimensional (3D) model of the cochlea that will be presented in this paper. The high quality of the histological images is being exploited in order to extract several sections of the cochlea that are not visible on the micro-CT (mCT) images (i.e., scala media, spiral ligament, and organ of Corti) as well as other important sections (i.e., basilar membrane, Reissner membrane, scala vestibule, and scala tympani). The reconstructed model is being projected in the centerline of the coiled cochlea, extracted from mCT images, and represented in the 3D space. The reconstruction activities are part of the SIFEM project, which will result in the delivery of an infrastructure, semantically interlinking various tools and libraries (i.e., segmentation, reconstruction, and visualization tools) with the clinical knowledge, which is represented by existing data, towards the delivery of a robust multiscale model of the inner ear. Hindawi Publishing Corporation 2014 2014-08-03 /pmc/articles/PMC4137506/ /pubmed/25157360 http://dx.doi.org/10.1155/2014/485783 Text en Copyright © 2014 Christos Bellos et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bellos, Christos
Rigas, George
Spiridon, Ioannis F.
Bibas, Athanasios
Iliopoulou, Dimitra
Böhnke, Frank
Koutsouris, Dimitrios
Fotiadis, Dimitrios I.
Reconstruction of Cochlea Based on Micro-CT and Histological Images of the Human Inner Ear
title Reconstruction of Cochlea Based on Micro-CT and Histological Images of the Human Inner Ear
title_full Reconstruction of Cochlea Based on Micro-CT and Histological Images of the Human Inner Ear
title_fullStr Reconstruction of Cochlea Based on Micro-CT and Histological Images of the Human Inner Ear
title_full_unstemmed Reconstruction of Cochlea Based on Micro-CT and Histological Images of the Human Inner Ear
title_short Reconstruction of Cochlea Based on Micro-CT and Histological Images of the Human Inner Ear
title_sort reconstruction of cochlea based on micro-ct and histological images of the human inner ear
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137506/
https://www.ncbi.nlm.nih.gov/pubmed/25157360
http://dx.doi.org/10.1155/2014/485783
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