Cargando…

Th17 Cells in Autoimmune and Infectious Diseases

The view of CD4 T-cell-mediated immunity as a balance between distinct lineages of Th1 and Th2 cells has changed dramatically. Identification of the IL-17 family of cytokines and of the fact that IL-23 mediates the expansion of IL-17-producing T cells uncovered a new subset of Th cells designated Th...

Descripción completa

Detalles Bibliográficos
Autores principales: Zambrano-Zaragoza, José Francisco, Romo-Martínez, Enrique Jhonatan, Durán-Avelar, Ma. de Jesús, García-Magallanes, Noemí, Vibanco-Pérez, Norberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137509/
https://www.ncbi.nlm.nih.gov/pubmed/25152827
http://dx.doi.org/10.1155/2014/651503
_version_ 1782331111069712384
author Zambrano-Zaragoza, José Francisco
Romo-Martínez, Enrique Jhonatan
Durán-Avelar, Ma. de Jesús
García-Magallanes, Noemí
Vibanco-Pérez, Norberto
author_facet Zambrano-Zaragoza, José Francisco
Romo-Martínez, Enrique Jhonatan
Durán-Avelar, Ma. de Jesús
García-Magallanes, Noemí
Vibanco-Pérez, Norberto
author_sort Zambrano-Zaragoza, José Francisco
collection PubMed
description The view of CD4 T-cell-mediated immunity as a balance between distinct lineages of Th1 and Th2 cells has changed dramatically. Identification of the IL-17 family of cytokines and of the fact that IL-23 mediates the expansion of IL-17-producing T cells uncovered a new subset of Th cells designated Th17 cells, which have emerged as a third independent T-cell subset that may play an essential role in protection against certain extracellular pathogens. Moreover, Th17 cells have been extensively analyzed because of their strong association with inflammatory disorders and autoimmune diseases. Also, they appear to be critical for controlling these disorders. Similar to Th1 and Th2 cells, Th17 cells require specific cytokines and transcription factors for their differentiation. Th17 cells have been characterized as one of the major pathogenic Th cell populations underlying the development of many autoimmune diseases, and they are enhanced and stabilized by IL-23. The characteristics of Th17 cells, cytokines, and their sources, as well as their role in infectious and autoimmune diseases, are discussed in this review.
format Online
Article
Text
id pubmed-4137509
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-41375092014-08-24 Th17 Cells in Autoimmune and Infectious Diseases Zambrano-Zaragoza, José Francisco Romo-Martínez, Enrique Jhonatan Durán-Avelar, Ma. de Jesús García-Magallanes, Noemí Vibanco-Pérez, Norberto Int J Inflam Review Article The view of CD4 T-cell-mediated immunity as a balance between distinct lineages of Th1 and Th2 cells has changed dramatically. Identification of the IL-17 family of cytokines and of the fact that IL-23 mediates the expansion of IL-17-producing T cells uncovered a new subset of Th cells designated Th17 cells, which have emerged as a third independent T-cell subset that may play an essential role in protection against certain extracellular pathogens. Moreover, Th17 cells have been extensively analyzed because of their strong association with inflammatory disorders and autoimmune diseases. Also, they appear to be critical for controlling these disorders. Similar to Th1 and Th2 cells, Th17 cells require specific cytokines and transcription factors for their differentiation. Th17 cells have been characterized as one of the major pathogenic Th cell populations underlying the development of many autoimmune diseases, and they are enhanced and stabilized by IL-23. The characteristics of Th17 cells, cytokines, and their sources, as well as their role in infectious and autoimmune diseases, are discussed in this review. Hindawi Publishing Corporation 2014 2014-08-03 /pmc/articles/PMC4137509/ /pubmed/25152827 http://dx.doi.org/10.1155/2014/651503 Text en Copyright © 2014 José Francisco Zambrano-Zaragoza et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zambrano-Zaragoza, José Francisco
Romo-Martínez, Enrique Jhonatan
Durán-Avelar, Ma. de Jesús
García-Magallanes, Noemí
Vibanco-Pérez, Norberto
Th17 Cells in Autoimmune and Infectious Diseases
title Th17 Cells in Autoimmune and Infectious Diseases
title_full Th17 Cells in Autoimmune and Infectious Diseases
title_fullStr Th17 Cells in Autoimmune and Infectious Diseases
title_full_unstemmed Th17 Cells in Autoimmune and Infectious Diseases
title_short Th17 Cells in Autoimmune and Infectious Diseases
title_sort th17 cells in autoimmune and infectious diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137509/
https://www.ncbi.nlm.nih.gov/pubmed/25152827
http://dx.doi.org/10.1155/2014/651503
work_keys_str_mv AT zambranozaragozajosefrancisco th17cellsinautoimmuneandinfectiousdiseases
AT romomartinezenriquejhonatan th17cellsinautoimmuneandinfectiousdiseases
AT duranavelarmadejesus th17cellsinautoimmuneandinfectiousdiseases
AT garciamagallanesnoemi th17cellsinautoimmuneandinfectiousdiseases
AT vibancopereznorberto th17cellsinautoimmuneandinfectiousdiseases