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Th17 Cells in Autoimmune and Infectious Diseases
The view of CD4 T-cell-mediated immunity as a balance between distinct lineages of Th1 and Th2 cells has changed dramatically. Identification of the IL-17 family of cytokines and of the fact that IL-23 mediates the expansion of IL-17-producing T cells uncovered a new subset of Th cells designated Th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137509/ https://www.ncbi.nlm.nih.gov/pubmed/25152827 http://dx.doi.org/10.1155/2014/651503 |
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author | Zambrano-Zaragoza, José Francisco Romo-Martínez, Enrique Jhonatan Durán-Avelar, Ma. de Jesús García-Magallanes, Noemí Vibanco-Pérez, Norberto |
author_facet | Zambrano-Zaragoza, José Francisco Romo-Martínez, Enrique Jhonatan Durán-Avelar, Ma. de Jesús García-Magallanes, Noemí Vibanco-Pérez, Norberto |
author_sort | Zambrano-Zaragoza, José Francisco |
collection | PubMed |
description | The view of CD4 T-cell-mediated immunity as a balance between distinct lineages of Th1 and Th2 cells has changed dramatically. Identification of the IL-17 family of cytokines and of the fact that IL-23 mediates the expansion of IL-17-producing T cells uncovered a new subset of Th cells designated Th17 cells, which have emerged as a third independent T-cell subset that may play an essential role in protection against certain extracellular pathogens. Moreover, Th17 cells have been extensively analyzed because of their strong association with inflammatory disorders and autoimmune diseases. Also, they appear to be critical for controlling these disorders. Similar to Th1 and Th2 cells, Th17 cells require specific cytokines and transcription factors for their differentiation. Th17 cells have been characterized as one of the major pathogenic Th cell populations underlying the development of many autoimmune diseases, and they are enhanced and stabilized by IL-23. The characteristics of Th17 cells, cytokines, and their sources, as well as their role in infectious and autoimmune diseases, are discussed in this review. |
format | Online Article Text |
id | pubmed-4137509 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41375092014-08-24 Th17 Cells in Autoimmune and Infectious Diseases Zambrano-Zaragoza, José Francisco Romo-Martínez, Enrique Jhonatan Durán-Avelar, Ma. de Jesús García-Magallanes, Noemí Vibanco-Pérez, Norberto Int J Inflam Review Article The view of CD4 T-cell-mediated immunity as a balance between distinct lineages of Th1 and Th2 cells has changed dramatically. Identification of the IL-17 family of cytokines and of the fact that IL-23 mediates the expansion of IL-17-producing T cells uncovered a new subset of Th cells designated Th17 cells, which have emerged as a third independent T-cell subset that may play an essential role in protection against certain extracellular pathogens. Moreover, Th17 cells have been extensively analyzed because of their strong association with inflammatory disorders and autoimmune diseases. Also, they appear to be critical for controlling these disorders. Similar to Th1 and Th2 cells, Th17 cells require specific cytokines and transcription factors for their differentiation. Th17 cells have been characterized as one of the major pathogenic Th cell populations underlying the development of many autoimmune diseases, and they are enhanced and stabilized by IL-23. The characteristics of Th17 cells, cytokines, and their sources, as well as their role in infectious and autoimmune diseases, are discussed in this review. Hindawi Publishing Corporation 2014 2014-08-03 /pmc/articles/PMC4137509/ /pubmed/25152827 http://dx.doi.org/10.1155/2014/651503 Text en Copyright © 2014 José Francisco Zambrano-Zaragoza et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zambrano-Zaragoza, José Francisco Romo-Martínez, Enrique Jhonatan Durán-Avelar, Ma. de Jesús García-Magallanes, Noemí Vibanco-Pérez, Norberto Th17 Cells in Autoimmune and Infectious Diseases |
title | Th17 Cells in Autoimmune and Infectious Diseases |
title_full | Th17 Cells in Autoimmune and Infectious Diseases |
title_fullStr | Th17 Cells in Autoimmune and Infectious Diseases |
title_full_unstemmed | Th17 Cells in Autoimmune and Infectious Diseases |
title_short | Th17 Cells in Autoimmune and Infectious Diseases |
title_sort | th17 cells in autoimmune and infectious diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137509/ https://www.ncbi.nlm.nih.gov/pubmed/25152827 http://dx.doi.org/10.1155/2014/651503 |
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