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Effects of Chinese Formula Jueyin Granules on Psoriasis in an Animal Model

Although Traditional Chinese medicine (TCM) is known to be effective for psoriasis patients, the responsible mechanisms still remain poorly understood. In this study, we aimed to evaluate the effect of one formula, named Jueyin granules (JYG) in the mouse model of the vaginal epithelium and tail epi...

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Autores principales: Ma, Tian, Jiang, Wen-cheng, Li, Xin, Chen, Jie, Wu, Tie-jun, Nian, Hua, Xu, Rong, Huang, Qian-yuan, Xiao, Qing-qing, Jian, Qiang, Li, Fu-lun, Li, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137608/
https://www.ncbi.nlm.nih.gov/pubmed/25165479
http://dx.doi.org/10.1155/2014/512562
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author Ma, Tian
Jiang, Wen-cheng
Li, Xin
Chen, Jie
Wu, Tie-jun
Nian, Hua
Xu, Rong
Huang, Qian-yuan
Xiao, Qing-qing
Jian, Qiang
Li, Fu-lun
Li, Bin
author_facet Ma, Tian
Jiang, Wen-cheng
Li, Xin
Chen, Jie
Wu, Tie-jun
Nian, Hua
Xu, Rong
Huang, Qian-yuan
Xiao, Qing-qing
Jian, Qiang
Li, Fu-lun
Li, Bin
author_sort Ma, Tian
collection PubMed
description Although Traditional Chinese medicine (TCM) is known to be effective for psoriasis patients, the responsible mechanisms still remain poorly understood. In this study, we aimed to evaluate the effect of one formula, named Jueyin granules (JYG) in the mouse model of the vaginal epithelium and tail epidermis. Additionally, we also determined the anti-inflammatory effects of JYG in an imiquimod- (IMQ-) induced psoriasis-like skin mouse model. Our results show that JYG can attenuate the IMQ-induced psoriasis-like inflammation, accompanied with increased epidermal hyperplasia. We also measured estrogenic stage mitosis of vaginal epithelial cells and the formation of granular cell layers in male mouse tails per 100 scales, as well as the tissue nitric oxide (NO) and malondialdehyde (MDA) levels using the ELISA method. The results suggest that JYG significantly inhibited mitosis in mouse vaginal epithelial cells, promoted the formation of the squamous epidermal granular layer in mice tails, and reduced the levels of NO and MDA in an imiquimod-induced psoriasis-like skin mouse model after 14 d (P < 0.05). These results demonstrate that JYG might be an effective clinical treatment for psoriasis and the effects may be related to inhibited keratinocytes proliferation, improved parakeratotic epidermal cells, and reduced expression of NO and MDA.
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spelling pubmed-41376082014-08-27 Effects of Chinese Formula Jueyin Granules on Psoriasis in an Animal Model Ma, Tian Jiang, Wen-cheng Li, Xin Chen, Jie Wu, Tie-jun Nian, Hua Xu, Rong Huang, Qian-yuan Xiao, Qing-qing Jian, Qiang Li, Fu-lun Li, Bin Evid Based Complement Alternat Med Research Article Although Traditional Chinese medicine (TCM) is known to be effective for psoriasis patients, the responsible mechanisms still remain poorly understood. In this study, we aimed to evaluate the effect of one formula, named Jueyin granules (JYG) in the mouse model of the vaginal epithelium and tail epidermis. Additionally, we also determined the anti-inflammatory effects of JYG in an imiquimod- (IMQ-) induced psoriasis-like skin mouse model. Our results show that JYG can attenuate the IMQ-induced psoriasis-like inflammation, accompanied with increased epidermal hyperplasia. We also measured estrogenic stage mitosis of vaginal epithelial cells and the formation of granular cell layers in male mouse tails per 100 scales, as well as the tissue nitric oxide (NO) and malondialdehyde (MDA) levels using the ELISA method. The results suggest that JYG significantly inhibited mitosis in mouse vaginal epithelial cells, promoted the formation of the squamous epidermal granular layer in mice tails, and reduced the levels of NO and MDA in an imiquimod-induced psoriasis-like skin mouse model after 14 d (P < 0.05). These results demonstrate that JYG might be an effective clinical treatment for psoriasis and the effects may be related to inhibited keratinocytes proliferation, improved parakeratotic epidermal cells, and reduced expression of NO and MDA. Hindawi Publishing Corporation 2014 2014-08-04 /pmc/articles/PMC4137608/ /pubmed/25165479 http://dx.doi.org/10.1155/2014/512562 Text en Copyright © 2014 Tian Ma et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ma, Tian
Jiang, Wen-cheng
Li, Xin
Chen, Jie
Wu, Tie-jun
Nian, Hua
Xu, Rong
Huang, Qian-yuan
Xiao, Qing-qing
Jian, Qiang
Li, Fu-lun
Li, Bin
Effects of Chinese Formula Jueyin Granules on Psoriasis in an Animal Model
title Effects of Chinese Formula Jueyin Granules on Psoriasis in an Animal Model
title_full Effects of Chinese Formula Jueyin Granules on Psoriasis in an Animal Model
title_fullStr Effects of Chinese Formula Jueyin Granules on Psoriasis in an Animal Model
title_full_unstemmed Effects of Chinese Formula Jueyin Granules on Psoriasis in an Animal Model
title_short Effects of Chinese Formula Jueyin Granules on Psoriasis in an Animal Model
title_sort effects of chinese formula jueyin granules on psoriasis in an animal model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137608/
https://www.ncbi.nlm.nih.gov/pubmed/25165479
http://dx.doi.org/10.1155/2014/512562
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