Concomitant Bifocal Urothelial Carcinoma and Breast Tumor: Second Primary Cancer or Metastatic Spread to the Breast?

Metastases to the mammary gland are an uncommon event in the natural history of most malignant tumors. We report the case of a 60-year-old woman who presented initially with bifocal urothelial carcinoma with a single breast tumor, raising the issue of a primary cancer or a metastatic spread to the b...

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Autores principales: Dumont, Clément, Gauthier, Hélène, Vérine, Jérôme, Lehmann-Che, Jacqueline, de Cremoux, Patricia, Pouessel, Damien, Culine, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137750/
https://www.ncbi.nlm.nih.gov/pubmed/25161789
http://dx.doi.org/10.1155/2014/917581
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author Dumont, Clément
Gauthier, Hélène
Vérine, Jérôme
Lehmann-Che, Jacqueline
de Cremoux, Patricia
Pouessel, Damien
Culine, Stéphane
author_facet Dumont, Clément
Gauthier, Hélène
Vérine, Jérôme
Lehmann-Che, Jacqueline
de Cremoux, Patricia
Pouessel, Damien
Culine, Stéphane
author_sort Dumont, Clément
collection PubMed
description Metastases to the mammary gland are an uncommon event in the natural history of most malignant tumors. We report the case of a 60-year-old woman who presented initially with bifocal urothelial carcinoma with a single breast tumor, raising the issue of a primary cancer or a metastatic spread to the breast. The diagnosis of breast metastasis was aided by identity of pathology, immunochemistry, and molecular biology findings between the primary tumor and the breast lesion, among which are the p.K120M mutation, a very rare TP53 mutation, and HER2 overexpression with underlying polysomy of chromosome 17.
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spelling pubmed-41377502014-08-26 Concomitant Bifocal Urothelial Carcinoma and Breast Tumor: Second Primary Cancer or Metastatic Spread to the Breast? Dumont, Clément Gauthier, Hélène Vérine, Jérôme Lehmann-Che, Jacqueline de Cremoux, Patricia Pouessel, Damien Culine, Stéphane Case Rep Oncol Med Case Report Metastases to the mammary gland are an uncommon event in the natural history of most malignant tumors. We report the case of a 60-year-old woman who presented initially with bifocal urothelial carcinoma with a single breast tumor, raising the issue of a primary cancer or a metastatic spread to the breast. The diagnosis of breast metastasis was aided by identity of pathology, immunochemistry, and molecular biology findings between the primary tumor and the breast lesion, among which are the p.K120M mutation, a very rare TP53 mutation, and HER2 overexpression with underlying polysomy of chromosome 17. Hindawi Publishing Corporation 2014 2014-08-04 /pmc/articles/PMC4137750/ /pubmed/25161789 http://dx.doi.org/10.1155/2014/917581 Text en Copyright © 2014 Clément Dumont et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Dumont, Clément
Gauthier, Hélène
Vérine, Jérôme
Lehmann-Che, Jacqueline
de Cremoux, Patricia
Pouessel, Damien
Culine, Stéphane
Concomitant Bifocal Urothelial Carcinoma and Breast Tumor: Second Primary Cancer or Metastatic Spread to the Breast?
title Concomitant Bifocal Urothelial Carcinoma and Breast Tumor: Second Primary Cancer or Metastatic Spread to the Breast?
title_full Concomitant Bifocal Urothelial Carcinoma and Breast Tumor: Second Primary Cancer or Metastatic Spread to the Breast?
title_fullStr Concomitant Bifocal Urothelial Carcinoma and Breast Tumor: Second Primary Cancer or Metastatic Spread to the Breast?
title_full_unstemmed Concomitant Bifocal Urothelial Carcinoma and Breast Tumor: Second Primary Cancer or Metastatic Spread to the Breast?
title_short Concomitant Bifocal Urothelial Carcinoma and Breast Tumor: Second Primary Cancer or Metastatic Spread to the Breast?
title_sort concomitant bifocal urothelial carcinoma and breast tumor: second primary cancer or metastatic spread to the breast?
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137750/
https://www.ncbi.nlm.nih.gov/pubmed/25161789
http://dx.doi.org/10.1155/2014/917581
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