Cargando…

Antioxidant effects of proanthocyanidin from grape seed on hepatic tissue injury in diabetic rats

OBJECTIVE(S): Diabetes plays an important role in the induction of the liver injury. Grape seed proanthocyanidin (GSP) have a wide range of medicinal properties against oxidative stress. In this study we evaluated antioxidant effects of GSP on liver in streptozotocin-induced diabetic rats. MATERIALS...

Descripción completa

Detalles Bibliográficos
Autores principales: Mansouri, Esrafil, Khorsandi, Layasadat, Abedi, Hassan Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137947/
https://www.ncbi.nlm.nih.gov/pubmed/25140209
_version_ 1782331168304136192
author Mansouri, Esrafil
Khorsandi, Layasadat
Abedi, Hassan Ali
author_facet Mansouri, Esrafil
Khorsandi, Layasadat
Abedi, Hassan Ali
author_sort Mansouri, Esrafil
collection PubMed
description OBJECTIVE(S): Diabetes plays an important role in the induction of the liver injury. Grape seed proanthocyanidin (GSP) have a wide range of medicinal properties against oxidative stress. In this study we evaluated antioxidant effects of GSP on liver in streptozotocin-induced diabetic rats. MATERIALS AND METHODS: Thirty male Sprague–Dawley rats were divided into three groups: control, untreated diabetic and diabetic rats treated with GSP. Diabetes was induced in rats by intraperitoneal injection of streptozotocin (50 mg/kg). GSP were administered via oral gavage (200 mg/kg) for 4 weeks. RESULTS: GSP produced significant hepatoprotective effects by decreasing activities of serum aminotransferases and alkaline phosphatase, and decreasing liver malondialdehyde and bilirubin (P<0.05) levels. It increased liver superoxide dismutase, catalase and glutathione peroxidase activities and albumin level (P<0.05). Administration of GSP significantly ameliorated structural changes induced in liver of diabetic rats. CONCLUSION: GSP have protective effects against hepatic tissue injury due to antioxidant properties.
format Online
Article
Text
id pubmed-4137947
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Mashhad University of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-41379472014-08-19 Antioxidant effects of proanthocyanidin from grape seed on hepatic tissue injury in diabetic rats Mansouri, Esrafil Khorsandi, Layasadat Abedi, Hassan Ali Iran J Basic Med Sci Short Communication OBJECTIVE(S): Diabetes plays an important role in the induction of the liver injury. Grape seed proanthocyanidin (GSP) have a wide range of medicinal properties against oxidative stress. In this study we evaluated antioxidant effects of GSP on liver in streptozotocin-induced diabetic rats. MATERIALS AND METHODS: Thirty male Sprague–Dawley rats were divided into three groups: control, untreated diabetic and diabetic rats treated with GSP. Diabetes was induced in rats by intraperitoneal injection of streptozotocin (50 mg/kg). GSP were administered via oral gavage (200 mg/kg) for 4 weeks. RESULTS: GSP produced significant hepatoprotective effects by decreasing activities of serum aminotransferases and alkaline phosphatase, and decreasing liver malondialdehyde and bilirubin (P<0.05) levels. It increased liver superoxide dismutase, catalase and glutathione peroxidase activities and albumin level (P<0.05). Administration of GSP significantly ameliorated structural changes induced in liver of diabetic rats. CONCLUSION: GSP have protective effects against hepatic tissue injury due to antioxidant properties. Mashhad University of Medical Sciences 2014-06 /pmc/articles/PMC4137947/ /pubmed/25140209 Text en Copyright: © Iranian Journal of Basic Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Mansouri, Esrafil
Khorsandi, Layasadat
Abedi, Hassan Ali
Antioxidant effects of proanthocyanidin from grape seed on hepatic tissue injury in diabetic rats
title Antioxidant effects of proanthocyanidin from grape seed on hepatic tissue injury in diabetic rats
title_full Antioxidant effects of proanthocyanidin from grape seed on hepatic tissue injury in diabetic rats
title_fullStr Antioxidant effects of proanthocyanidin from grape seed on hepatic tissue injury in diabetic rats
title_full_unstemmed Antioxidant effects of proanthocyanidin from grape seed on hepatic tissue injury in diabetic rats
title_short Antioxidant effects of proanthocyanidin from grape seed on hepatic tissue injury in diabetic rats
title_sort antioxidant effects of proanthocyanidin from grape seed on hepatic tissue injury in diabetic rats
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137947/
https://www.ncbi.nlm.nih.gov/pubmed/25140209
work_keys_str_mv AT mansouriesrafil antioxidanteffectsofproanthocyanidinfromgrapeseedonhepatictissueinjuryindiabeticrats
AT khorsandilayasadat antioxidanteffectsofproanthocyanidinfromgrapeseedonhepatictissueinjuryindiabeticrats
AT abedihassanali antioxidanteffectsofproanthocyanidinfromgrapeseedonhepatictissueinjuryindiabeticrats