Cargando…
Association between Thrombomodulin Polymorphisms and Coronary Artery Disease Risk: A Meta-Analysis
BACKGROUND: The associations between the thrombomodulin (TM) polymorphisms and coronary artery disease (CAD) risk remain controversial. The aim of this study was to evaluate the association of TM polymorphisms with CAD susceptibility using a meta-analysis approach. MATERIAL/METHODS: All eligible stu...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138070/ https://www.ncbi.nlm.nih.gov/pubmed/25108690 http://dx.doi.org/10.12659/MSM.890717 |
_version_ | 1782331185855201280 |
---|---|
author | Zhang, Shuai Zhang, Zhe Zhang, Feng Wei, Chuanxiang Bu, Ying Zheng, Siliang Su, Dexing |
author_facet | Zhang, Shuai Zhang, Zhe Zhang, Feng Wei, Chuanxiang Bu, Ying Zheng, Siliang Su, Dexing |
author_sort | Zhang, Shuai |
collection | PubMed |
description | BACKGROUND: The associations between the thrombomodulin (TM) polymorphisms and coronary artery disease (CAD) risk remain controversial. The aim of this study was to evaluate the association of TM polymorphisms with CAD susceptibility using a meta-analysis approach. MATERIAL/METHODS: All eligible studies were identified through a search of PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) before February 2014. The associations between the TM polymorphisms and CAD risk was assessed by odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: A total of 14 case-control studies, including 5493 cases and 8297 controls, were eventually collected. There was a significant association between TM -33G/A polymorphism and CAD risk (OR=1.61; 95% CI, 1.35–1.92; I(2)=15%). The TM Ala455Val polymorphism was also associated with a significantly increased CAD risk (OR=1.14; 95% CI, 1.05–1.24; I(2)=0%). These results remained statistically significant when the adjusted ORs were combined. CONCLUSIONS: Our results suggest that TM-33G/A and Ala455Val polymorphisms are risk factors for CAD. |
format | Online Article Text |
id | pubmed-4138070 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-41380702014-08-21 Association between Thrombomodulin Polymorphisms and Coronary Artery Disease Risk: A Meta-Analysis Zhang, Shuai Zhang, Zhe Zhang, Feng Wei, Chuanxiang Bu, Ying Zheng, Siliang Su, Dexing Med Sci Monit Review Articles BACKGROUND: The associations between the thrombomodulin (TM) polymorphisms and coronary artery disease (CAD) risk remain controversial. The aim of this study was to evaluate the association of TM polymorphisms with CAD susceptibility using a meta-analysis approach. MATERIAL/METHODS: All eligible studies were identified through a search of PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) before February 2014. The associations between the TM polymorphisms and CAD risk was assessed by odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: A total of 14 case-control studies, including 5493 cases and 8297 controls, were eventually collected. There was a significant association between TM -33G/A polymorphism and CAD risk (OR=1.61; 95% CI, 1.35–1.92; I(2)=15%). The TM Ala455Val polymorphism was also associated with a significantly increased CAD risk (OR=1.14; 95% CI, 1.05–1.24; I(2)=0%). These results remained statistically significant when the adjusted ORs were combined. CONCLUSIONS: Our results suggest that TM-33G/A and Ala455Val polymorphisms are risk factors for CAD. International Scientific Literature, Inc. 2014-08-10 /pmc/articles/PMC4138070/ /pubmed/25108690 http://dx.doi.org/10.12659/MSM.890717 Text en © Med Sci Monit, 2014 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License |
spellingShingle | Review Articles Zhang, Shuai Zhang, Zhe Zhang, Feng Wei, Chuanxiang Bu, Ying Zheng, Siliang Su, Dexing Association between Thrombomodulin Polymorphisms and Coronary Artery Disease Risk: A Meta-Analysis |
title | Association between Thrombomodulin Polymorphisms and Coronary Artery Disease Risk: A Meta-Analysis |
title_full | Association between Thrombomodulin Polymorphisms and Coronary Artery Disease Risk: A Meta-Analysis |
title_fullStr | Association between Thrombomodulin Polymorphisms and Coronary Artery Disease Risk: A Meta-Analysis |
title_full_unstemmed | Association between Thrombomodulin Polymorphisms and Coronary Artery Disease Risk: A Meta-Analysis |
title_short | Association between Thrombomodulin Polymorphisms and Coronary Artery Disease Risk: A Meta-Analysis |
title_sort | association between thrombomodulin polymorphisms and coronary artery disease risk: a meta-analysis |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138070/ https://www.ncbi.nlm.nih.gov/pubmed/25108690 http://dx.doi.org/10.12659/MSM.890717 |
work_keys_str_mv | AT zhangshuai associationbetweenthrombomodulinpolymorphismsandcoronaryarterydiseaseriskametaanalysis AT zhangzhe associationbetweenthrombomodulinpolymorphismsandcoronaryarterydiseaseriskametaanalysis AT zhangfeng associationbetweenthrombomodulinpolymorphismsandcoronaryarterydiseaseriskametaanalysis AT weichuanxiang associationbetweenthrombomodulinpolymorphismsandcoronaryarterydiseaseriskametaanalysis AT buying associationbetweenthrombomodulinpolymorphismsandcoronaryarterydiseaseriskametaanalysis AT zhengsiliang associationbetweenthrombomodulinpolymorphismsandcoronaryarterydiseaseriskametaanalysis AT sudexing associationbetweenthrombomodulinpolymorphismsandcoronaryarterydiseaseriskametaanalysis |