Cargando…

Association between Thrombomodulin Polymorphisms and Coronary Artery Disease Risk: A Meta-Analysis

BACKGROUND: The associations between the thrombomodulin (TM) polymorphisms and coronary artery disease (CAD) risk remain controversial. The aim of this study was to evaluate the association of TM polymorphisms with CAD susceptibility using a meta-analysis approach. MATERIAL/METHODS: All eligible stu...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Shuai, Zhang, Zhe, Zhang, Feng, Wei, Chuanxiang, Bu, Ying, Zheng, Siliang, Su, Dexing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138070/
https://www.ncbi.nlm.nih.gov/pubmed/25108690
http://dx.doi.org/10.12659/MSM.890717
_version_ 1782331185855201280
author Zhang, Shuai
Zhang, Zhe
Zhang, Feng
Wei, Chuanxiang
Bu, Ying
Zheng, Siliang
Su, Dexing
author_facet Zhang, Shuai
Zhang, Zhe
Zhang, Feng
Wei, Chuanxiang
Bu, Ying
Zheng, Siliang
Su, Dexing
author_sort Zhang, Shuai
collection PubMed
description BACKGROUND: The associations between the thrombomodulin (TM) polymorphisms and coronary artery disease (CAD) risk remain controversial. The aim of this study was to evaluate the association of TM polymorphisms with CAD susceptibility using a meta-analysis approach. MATERIAL/METHODS: All eligible studies were identified through a search of PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) before February 2014. The associations between the TM polymorphisms and CAD risk was assessed by odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: A total of 14 case-control studies, including 5493 cases and 8297 controls, were eventually collected. There was a significant association between TM -33G/A polymorphism and CAD risk (OR=1.61; 95% CI, 1.35–1.92; I(2)=15%). The TM Ala455Val polymorphism was also associated with a significantly increased CAD risk (OR=1.14; 95% CI, 1.05–1.24; I(2)=0%). These results remained statistically significant when the adjusted ORs were combined. CONCLUSIONS: Our results suggest that TM-33G/A and Ala455Val polymorphisms are risk factors for CAD.
format Online
Article
Text
id pubmed-4138070
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher International Scientific Literature, Inc.
record_format MEDLINE/PubMed
spelling pubmed-41380702014-08-21 Association between Thrombomodulin Polymorphisms and Coronary Artery Disease Risk: A Meta-Analysis Zhang, Shuai Zhang, Zhe Zhang, Feng Wei, Chuanxiang Bu, Ying Zheng, Siliang Su, Dexing Med Sci Monit Review Articles BACKGROUND: The associations between the thrombomodulin (TM) polymorphisms and coronary artery disease (CAD) risk remain controversial. The aim of this study was to evaluate the association of TM polymorphisms with CAD susceptibility using a meta-analysis approach. MATERIAL/METHODS: All eligible studies were identified through a search of PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) before February 2014. The associations between the TM polymorphisms and CAD risk was assessed by odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: A total of 14 case-control studies, including 5493 cases and 8297 controls, were eventually collected. There was a significant association between TM -33G/A polymorphism and CAD risk (OR=1.61; 95% CI, 1.35–1.92; I(2)=15%). The TM Ala455Val polymorphism was also associated with a significantly increased CAD risk (OR=1.14; 95% CI, 1.05–1.24; I(2)=0%). These results remained statistically significant when the adjusted ORs were combined. CONCLUSIONS: Our results suggest that TM-33G/A and Ala455Val polymorphisms are risk factors for CAD. International Scientific Literature, Inc. 2014-08-10 /pmc/articles/PMC4138070/ /pubmed/25108690 http://dx.doi.org/10.12659/MSM.890717 Text en © Med Sci Monit, 2014 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
spellingShingle Review Articles
Zhang, Shuai
Zhang, Zhe
Zhang, Feng
Wei, Chuanxiang
Bu, Ying
Zheng, Siliang
Su, Dexing
Association between Thrombomodulin Polymorphisms and Coronary Artery Disease Risk: A Meta-Analysis
title Association between Thrombomodulin Polymorphisms and Coronary Artery Disease Risk: A Meta-Analysis
title_full Association between Thrombomodulin Polymorphisms and Coronary Artery Disease Risk: A Meta-Analysis
title_fullStr Association between Thrombomodulin Polymorphisms and Coronary Artery Disease Risk: A Meta-Analysis
title_full_unstemmed Association between Thrombomodulin Polymorphisms and Coronary Artery Disease Risk: A Meta-Analysis
title_short Association between Thrombomodulin Polymorphisms and Coronary Artery Disease Risk: A Meta-Analysis
title_sort association between thrombomodulin polymorphisms and coronary artery disease risk: a meta-analysis
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138070/
https://www.ncbi.nlm.nih.gov/pubmed/25108690
http://dx.doi.org/10.12659/MSM.890717
work_keys_str_mv AT zhangshuai associationbetweenthrombomodulinpolymorphismsandcoronaryarterydiseaseriskametaanalysis
AT zhangzhe associationbetweenthrombomodulinpolymorphismsandcoronaryarterydiseaseriskametaanalysis
AT zhangfeng associationbetweenthrombomodulinpolymorphismsandcoronaryarterydiseaseriskametaanalysis
AT weichuanxiang associationbetweenthrombomodulinpolymorphismsandcoronaryarterydiseaseriskametaanalysis
AT buying associationbetweenthrombomodulinpolymorphismsandcoronaryarterydiseaseriskametaanalysis
AT zhengsiliang associationbetweenthrombomodulinpolymorphismsandcoronaryarterydiseaseriskametaanalysis
AT sudexing associationbetweenthrombomodulinpolymorphismsandcoronaryarterydiseaseriskametaanalysis