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Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase
The PTH receptor is one of the first GPCR found to sustain cAMP signaling after internalization of the ligand–receptor complex in endosomes. This unexpected model is adding a new dimension on how we think about GPCR signaling, but its mechanism is incompletely understood. We report here that endosom...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138287/ https://www.ncbi.nlm.nih.gov/pubmed/25064832 http://dx.doi.org/10.1038/nchembio.1589 |