A roadmap to evaluate the proteome-wide selectivity of covalent kinase inhibitors

Kinases are principal components of signal transduction pathways and the focus of intense basic and drug discovery research. Irreversible inhibitors that covalently modify non-catalytic cysteines in kinase active-sites have emerged as valuable probes and approved drugs. Many protein classes, however...

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Detalles Bibliográficos
Autores principales: Lanning, Bryan R., Whitby, Landon R., Dix, Melissa M., Douhan, John, Gilbert, Adam M., Hett, Erik C., Johnson, Theodore O., Joslyn, Chris, Kath, John C., Niessen, Sherry, Roberts, Lee R., Schnute, Mark E., Wang, Chu, Hulce, Jonathan J., Wei, Baoxian, Whiteley, Laurence O., Hayward, Matthew M., Cravatt, Benjamin F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138289/
https://www.ncbi.nlm.nih.gov/pubmed/25038787
http://dx.doi.org/10.1038/nchembio.1582

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