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A unifying model of the role of the infralimbic cortex in extinction and habits

The infralimbic prefrontal cortex (IL) has been shown to be critical for the regulation of flexible behavior, but its precise function remains unclear. This region has been shown to be critical for the acquisition, consolidation, and expression of extinction learning, leading many to hypothesize tha...

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Detalles Bibliográficos
Autores principales: Barker, Jacqueline M., Taylor, Jane R., Chandler, L. Judson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138355/
https://www.ncbi.nlm.nih.gov/pubmed/25128534
http://dx.doi.org/10.1101/lm.035501.114
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author Barker, Jacqueline M.
Taylor, Jane R.
Chandler, L. Judson
author_facet Barker, Jacqueline M.
Taylor, Jane R.
Chandler, L. Judson
author_sort Barker, Jacqueline M.
collection PubMed
description The infralimbic prefrontal cortex (IL) has been shown to be critical for the regulation of flexible behavior, but its precise function remains unclear. This region has been shown to be critical for the acquisition, consolidation, and expression of extinction learning, leading many to hypothesize that IL suppresses behavior as part of a “stop” network. However, this framework is at odds with IL function in habitual behavior in which the IL has been shown to be required for the expression and acquisition of ongoing habitual behavior. Here, we will review the current state of knowledge of IL anatomy and function in behavioral flexibility and provide a testable framework for a single IL mechanism underlying its function in both extinction and habit learning.
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spelling pubmed-41383552015-09-01 A unifying model of the role of the infralimbic cortex in extinction and habits Barker, Jacqueline M. Taylor, Jane R. Chandler, L. Judson Learn Mem Review The infralimbic prefrontal cortex (IL) has been shown to be critical for the regulation of flexible behavior, but its precise function remains unclear. This region has been shown to be critical for the acquisition, consolidation, and expression of extinction learning, leading many to hypothesize that IL suppresses behavior as part of a “stop” network. However, this framework is at odds with IL function in habitual behavior in which the IL has been shown to be required for the expression and acquisition of ongoing habitual behavior. Here, we will review the current state of knowledge of IL anatomy and function in behavioral flexibility and provide a testable framework for a single IL mechanism underlying its function in both extinction and habit learning. Cold Spring Harbor Laboratory Press 2014-09 /pmc/articles/PMC4138355/ /pubmed/25128534 http://dx.doi.org/10.1101/lm.035501.114 Text en © 2014 Barker et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Review
Barker, Jacqueline M.
Taylor, Jane R.
Chandler, L. Judson
A unifying model of the role of the infralimbic cortex in extinction and habits
title A unifying model of the role of the infralimbic cortex in extinction and habits
title_full A unifying model of the role of the infralimbic cortex in extinction and habits
title_fullStr A unifying model of the role of the infralimbic cortex in extinction and habits
title_full_unstemmed A unifying model of the role of the infralimbic cortex in extinction and habits
title_short A unifying model of the role of the infralimbic cortex in extinction and habits
title_sort unifying model of the role of the infralimbic cortex in extinction and habits
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138355/
https://www.ncbi.nlm.nih.gov/pubmed/25128534
http://dx.doi.org/10.1101/lm.035501.114
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