Identification of Essential Histidine Residues Involved in Heme Binding and Hemozoin Formation in Heme Detoxification Protein from Plasmodium falciparum

Malaria parasites digest hemoglobin within a food vacuole to supply amino acids, releasing the toxic product heme. During the detoxification, toxic free heme is converted into an insoluble crystalline form called hemozoin (Hz). Heme detoxification protein (HDP) in Plasmodium falciparum is one of the...

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Detalles Bibliográficos
Autores principales: Nakatani, Keisuke, Ishikawa, Haruto, Aono, Shigetoshi, Mizutani, Yasuhisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138515/
https://www.ncbi.nlm.nih.gov/pubmed/25138161
http://dx.doi.org/10.1038/srep06137

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