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Efficacy of insulin lispro in improving glycemic control in gestational diabetes

AIM: To assess the safety and efficacy of insulin lispro in improving glycemic control in patients with gestational diabetes. MATERIALS AND METHODS: A retrospective observational study was conducted at a single center on 201 gestational women with diabetes. Subjects who received insulin lispro perfo...

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Detalles Bibliográficos
Autores principales: Deepaklal, M.C., Joseph, Kurian, Kurian, Rekha, Thakkar, Nandita A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138903/
https://www.ncbi.nlm.nih.gov/pubmed/25143904
http://dx.doi.org/10.4103/2230-8210.137492
Descripción
Sumario:AIM: To assess the safety and efficacy of insulin lispro in improving glycemic control in patients with gestational diabetes. MATERIALS AND METHODS: A retrospective observational study was conducted at a single center on 201 gestational women with diabetes. Subjects who received insulin lispro performed blood glucose self-monitoring and recorded the readings in the fasting state and 1 h after each meal. At each contact (in person or telephonic contact), the insulin dose was adjusted based on the readings measured. A total of 53 subjects also recorded glucose levels post-partum. Pregnancy and post-delivery glucose level and insulin requirements of these 53 patients were compared. RESULTS: Analysis of glucose levels both fasting and post-prandial glucose levels revealed that after using insulin lispro, the number of episodes of post-prandial hyperglycemia (1 h plasma glucose >120 mg/dL) was minimal and so was the incidence of hypoglycemia. Hypoglycemia was defined as a blood sugar value of. There was neither any congenital abnormality except for a poorly formed pinna in the right ear of one baby nor any post-partum complications of note. CONCLUSION: Insulin lispro is an effective and safe treatment option in gestational diabetes.