Building a Better Dynasore: The Dyngo Compounds Potently Inhibit Dynamin and Endocytosis

Dynamin GTPase activity increases when it oligomerizes either into helices in the presence of lipid templates or into rings in the presence of SH3 domain proteins. Dynasore is a dynamin inhibitor of moderate potency (IC(50) ˜ 15 μM in vitro). We show that dynasore binds stoichiometrically to deterge...

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Detalles Bibliográficos
Autores principales: McCluskey, Adam, Daniel, James A., Hadzic, Gordana, Chau, Ngoc, Clayton, Emma L., Mariana, Anna, Whiting, Ainslie, Gorgani, Nick N., Lloyd, Jonathan, Quan, Annie, Moshkanbaryans, Lia, Krishnan, Sai, Perera, Swetha, Chircop, Megan, von Kleist, Lisa, McGeachie, Andrew B., Howes, Mark T., Parton, Robert G., Campbell, Michael, Sakoff, Jennette A., Wang, Xuefeng, Sun, Jian‐Yuan, Robertson, Mark J., Deane, Fiona M., Nguyen, Tam H., Meunier, Frederic A., Cousin, Michael A., Robinson, Phillip J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons A/S 2013
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138991/
https://www.ncbi.nlm.nih.gov/pubmed/24025110
http://dx.doi.org/10.1111/tra.12119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138991/
https://www.ncbi.nlm.nih.gov/pubmed/24025110
http://dx.doi.org/10.1111/tra.12119

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