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CLEC‐2‐dependent activation of mouse platelets is weakly inhibited by cAMP but not by cGMP

BACKGROUND: The activation of platelet CLEC‐2 by podoplanin on lymphatic endothelial cells (LECs) has a critical role in prevention of mixing of lymphatic and blood vasculatures during embryonic development. Paradoxically, LECs release cAMP and cGMP‐elevating agents, prostacyclin (PGI(2)) and nitric...

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Detalles Bibliográficos
Autores principales:	Borgognone, A., Navarro‐Núñez, L., Correia, J. N., Pollitt, A. Y., Thomas, S. G., Eble, J. A., Pulcinelli, F. M., Madhani, M., Watson, S. P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Pub 2014
Materias:	PLATELETS
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138994/ https://www.ncbi.nlm.nih.gov/pubmed/24460629 http://dx.doi.org/10.1111/jth.12514

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