Rhodium-Catalyzed Ketone Methylation Using Methanol Under Mild Conditions: Formation of α-Branched Products**

The rhodium-catalyzed methylation of ketones has been accomplished using methanol as the methylating agent and the hydrogen-borrowing method. The sequence is notable for the relatively low temperatures that are required and for the ability of the reaction system to form α-branched products with ease...

Descripción completa

Detalles Bibliográficos
Autores principales: Chan, Louis K M, Poole, Darren L, Shen, Di, Healy, Mark P, Donohoe, Timothy J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2014
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138999/
https://www.ncbi.nlm.nih.gov/pubmed/24288297
http://dx.doi.org/10.1002/anie.201307950
_version_ 1782331309179273216
author Chan, Louis K M
Poole, Darren L
Shen, Di
Healy, Mark P
Donohoe, Timothy J
author_facet Chan, Louis K M
Poole, Darren L
Shen, Di
Healy, Mark P
Donohoe, Timothy J
author_sort Chan, Louis K M
collection PubMed
description The rhodium-catalyzed methylation of ketones has been accomplished using methanol as the methylating agent and the hydrogen-borrowing method. The sequence is notable for the relatively low temperatures that are required and for the ability of the reaction system to form α-branched products with ease. Doubly alkylated ketones can be prepared from methyl ketones and two different alcohols by using a sequential one-pot iridium- and rhodium-catalyzed process.
format Online
Article
Text
id pubmed-4138999
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher WILEY-VCH Verlag
record_format MEDLINE/PubMed
spelling pubmed-41389992014-09-22 Rhodium-Catalyzed Ketone Methylation Using Methanol Under Mild Conditions: Formation of α-Branched Products** Chan, Louis K M Poole, Darren L Shen, Di Healy, Mark P Donohoe, Timothy J Angew Chem Int Ed Engl Communications The rhodium-catalyzed methylation of ketones has been accomplished using methanol as the methylating agent and the hydrogen-borrowing method. The sequence is notable for the relatively low temperatures that are required and for the ability of the reaction system to form α-branched products with ease. Doubly alkylated ketones can be prepared from methyl ketones and two different alcohols by using a sequential one-pot iridium- and rhodium-catalyzed process. WILEY-VCH Verlag 2014-01-13 2013-11-29 /pmc/articles/PMC4138999/ /pubmed/24288297 http://dx.doi.org/10.1002/anie.201307950 Text en © 2014 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Chan, Louis K M
Poole, Darren L
Shen, Di
Healy, Mark P
Donohoe, Timothy J
Rhodium-Catalyzed Ketone Methylation Using Methanol Under Mild Conditions: Formation of α-Branched Products**
title Rhodium-Catalyzed Ketone Methylation Using Methanol Under Mild Conditions: Formation of α-Branched Products**
title_full Rhodium-Catalyzed Ketone Methylation Using Methanol Under Mild Conditions: Formation of α-Branched Products**
title_fullStr Rhodium-Catalyzed Ketone Methylation Using Methanol Under Mild Conditions: Formation of α-Branched Products**
title_full_unstemmed Rhodium-Catalyzed Ketone Methylation Using Methanol Under Mild Conditions: Formation of α-Branched Products**
title_short Rhodium-Catalyzed Ketone Methylation Using Methanol Under Mild Conditions: Formation of α-Branched Products**
title_sort rhodium-catalyzed ketone methylation using methanol under mild conditions: formation of α-branched products**
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138999/
https://www.ncbi.nlm.nih.gov/pubmed/24288297
http://dx.doi.org/10.1002/anie.201307950
work_keys_str_mv AT chanlouiskm rhodiumcatalyzedketonemethylationusingmethanolundermildconditionsformationofabranchedproducts
AT pooledarrenl rhodiumcatalyzedketonemethylationusingmethanolundermildconditionsformationofabranchedproducts
AT shendi rhodiumcatalyzedketonemethylationusingmethanolundermildconditionsformationofabranchedproducts
AT healymarkp rhodiumcatalyzedketonemethylationusingmethanolundermildconditionsformationofabranchedproducts
AT donohoetimothyj rhodiumcatalyzedketonemethylationusingmethanolundermildconditionsformationofabranchedproducts

Ejemplares similares