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Centella asiatica Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats
Diabetes mellitus has been reported to affect functions of the hippocampus. We hypothesized that Centella asiatica, a herb traditionally being used to improve memory, prevents diabetes-related hippocampal dysfunction. Therefore, the aim of this study was to investigate the protective role of C. asia...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139016/ https://www.ncbi.nlm.nih.gov/pubmed/25161691 http://dx.doi.org/10.1155/2014/592062 |
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author | Giribabu, Nelli Srinivasarao, Nelli Swapna Rekha, Somesula Muniandy, Sekaran Salleh, Naguib |
author_facet | Giribabu, Nelli Srinivasarao, Nelli Swapna Rekha, Somesula Muniandy, Sekaran Salleh, Naguib |
author_sort | Giribabu, Nelli |
collection | PubMed |
description | Diabetes mellitus has been reported to affect functions of the hippocampus. We hypothesized that Centella asiatica, a herb traditionally being used to improve memory, prevents diabetes-related hippocampal dysfunction. Therefore, the aim of this study was to investigate the protective role of C. asiatica on the hippocampus in diabetes. Methods. Streptozotocin- (STZ-) induced adult male diabetic rats received 100 and 200 mg/kg/day body weight (b.w) C. asiatica leaf aqueous extract for four consecutive weeks. Following sacrifice, hippocampus was removed and hippocampal tissue homogenates were analyzed for Na(+)/K(+)-, Ca(2+)- and Mg(2+)-ATPases activity levels. Levels of the markers of inflammation (tumor necrosis factor, TNF-α; interleukin, IL-6; and interleukin, IL-1β) and oxidative stress (lipid peroxidation product: LPO, superoxide dismutase: SOD, catalase: CAT, and glutathione peroxidase: GPx) were determined. The hippocampal sections were visualized for histopathological changes. Results. Administration of C. asiatica leaf aqueous extract to diabetic rats maintained near normal ATPases activity levels and prevents the increase in the levels of inflammatory and oxidative stress markers in the hippocampus. Lesser signs of histopathological changes were observed in the hippocampus of C. asiatica leaf aqueous extract treated diabetic rats. Conclusions. C. asiatica leaf protects the hippocampus against diabetes-induced dysfunction which could help to preserve memory in this condition. |
format | Online Article Text |
id | pubmed-4139016 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41390162014-08-26 Centella asiatica Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats Giribabu, Nelli Srinivasarao, Nelli Swapna Rekha, Somesula Muniandy, Sekaran Salleh, Naguib Evid Based Complement Alternat Med Research Article Diabetes mellitus has been reported to affect functions of the hippocampus. We hypothesized that Centella asiatica, a herb traditionally being used to improve memory, prevents diabetes-related hippocampal dysfunction. Therefore, the aim of this study was to investigate the protective role of C. asiatica on the hippocampus in diabetes. Methods. Streptozotocin- (STZ-) induced adult male diabetic rats received 100 and 200 mg/kg/day body weight (b.w) C. asiatica leaf aqueous extract for four consecutive weeks. Following sacrifice, hippocampus was removed and hippocampal tissue homogenates were analyzed for Na(+)/K(+)-, Ca(2+)- and Mg(2+)-ATPases activity levels. Levels of the markers of inflammation (tumor necrosis factor, TNF-α; interleukin, IL-6; and interleukin, IL-1β) and oxidative stress (lipid peroxidation product: LPO, superoxide dismutase: SOD, catalase: CAT, and glutathione peroxidase: GPx) were determined. The hippocampal sections were visualized for histopathological changes. Results. Administration of C. asiatica leaf aqueous extract to diabetic rats maintained near normal ATPases activity levels and prevents the increase in the levels of inflammatory and oxidative stress markers in the hippocampus. Lesser signs of histopathological changes were observed in the hippocampus of C. asiatica leaf aqueous extract treated diabetic rats. Conclusions. C. asiatica leaf protects the hippocampus against diabetes-induced dysfunction which could help to preserve memory in this condition. Hindawi Publishing Corporation 2014 2014-08-05 /pmc/articles/PMC4139016/ /pubmed/25161691 http://dx.doi.org/10.1155/2014/592062 Text en Copyright © 2014 Nelli Giribabu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Giribabu, Nelli Srinivasarao, Nelli Swapna Rekha, Somesula Muniandy, Sekaran Salleh, Naguib Centella asiatica Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats |
title |
Centella asiatica Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats |
title_full |
Centella asiatica Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats |
title_fullStr |
Centella asiatica Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats |
title_full_unstemmed |
Centella asiatica Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats |
title_short |
Centella asiatica Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats |
title_sort | centella asiatica attenuates diabetes induced hippocampal changes in experimental diabetic rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139016/ https://www.ncbi.nlm.nih.gov/pubmed/25161691 http://dx.doi.org/10.1155/2014/592062 |
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