Congenital Defects in Neutrophil Dynamics

Neutrophil granulocytes are key effector cells of the vertebrate immune system. They represent 50–70% of the leukocytes in the human blood and their loss by disease or drug side effect causes devastating bacterial infections. Their high turnover rate, their fine-tuned killing machinery, and their ar...

Descripción completa

Detalles Bibliográficos
Autores principales: Keszei, Marton, Westerberg, Lisa S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139026/
https://www.ncbi.nlm.nih.gov/pubmed/25165726
http://dx.doi.org/10.1155/2014/303782
_version_ 1782331313347362816
author Keszei, Marton
Westerberg, Lisa S.
author_facet Keszei, Marton
Westerberg, Lisa S.
author_sort Keszei, Marton
collection PubMed
description Neutrophil granulocytes are key effector cells of the vertebrate immune system. They represent 50–70% of the leukocytes in the human blood and their loss by disease or drug side effect causes devastating bacterial infections. Their high turnover rate, their fine-tuned killing machinery, and their arsenal of toxic vesicles leave them particularly vulnerable to various genetic deficiencies. The aim of this review is to highlight those congenital immunodeficiencies which impede the dynamics of neutrophils, such as migration, cytoskeletal rearrangements, vesicular trafficking, and secretion.
format Online
Article
Text
id pubmed-4139026
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-41390262014-08-27 Congenital Defects in Neutrophil Dynamics Keszei, Marton Westerberg, Lisa S. J Immunol Res Review Article Neutrophil granulocytes are key effector cells of the vertebrate immune system. They represent 50–70% of the leukocytes in the human blood and their loss by disease or drug side effect causes devastating bacterial infections. Their high turnover rate, their fine-tuned killing machinery, and their arsenal of toxic vesicles leave them particularly vulnerable to various genetic deficiencies. The aim of this review is to highlight those congenital immunodeficiencies which impede the dynamics of neutrophils, such as migration, cytoskeletal rearrangements, vesicular trafficking, and secretion. Hindawi Publishing Corporation 2014 2014-08-05 /pmc/articles/PMC4139026/ /pubmed/25165726 http://dx.doi.org/10.1155/2014/303782 Text en Copyright © 2014 M. Keszei and L. S. Westerberg. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Keszei, Marton
Westerberg, Lisa S.
Congenital Defects in Neutrophil Dynamics
title Congenital Defects in Neutrophil Dynamics
title_full Congenital Defects in Neutrophil Dynamics
title_fullStr Congenital Defects in Neutrophil Dynamics
title_full_unstemmed Congenital Defects in Neutrophil Dynamics
title_short Congenital Defects in Neutrophil Dynamics
title_sort congenital defects in neutrophil dynamics
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139026/
https://www.ncbi.nlm.nih.gov/pubmed/25165726
http://dx.doi.org/10.1155/2014/303782
work_keys_str_mv AT keszeimarton congenitaldefectsinneutrophildynamics
AT westerberglisas congenitaldefectsinneutrophildynamics

Ejemplares similares