Detection of Intermediates in the Oxidative Half-Reaction of the FAD-Dependent Thymidylate Synthase from Thermotoga maritima: Carbon Transfer without Covalent Pyrimidine Activation

[Image: see text] Thymidylate, a vital DNA precursor, is synthesized by thymidylate synthases (TSs). A second class of TSs, encoded by the thyX gene, is found in bacteria and a few other microbes and is especially widespread in anaerobes. TS encoded by thyX requires a flavin adenine dinucleotide pro...

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Detalles Bibliográficos
Autores principales: Conrad, John A., Ortiz-Maldonado, Mariliz, Hoppe, Samuel W., Palfey, Bruce A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139161/
https://www.ncbi.nlm.nih.gov/pubmed/25068636
http://dx.doi.org/10.1021/bi500648n

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139161/
https://www.ncbi.nlm.nih.gov/pubmed/25068636
http://dx.doi.org/10.1021/bi500648n

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