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Detection of Intermediates in the Oxidative Half-Reaction of the FAD-Dependent Thymidylate Synthase from Thermotoga maritima: Carbon Transfer without Covalent Pyrimidine Activation
[Image: see text] Thymidylate, a vital DNA precursor, is synthesized by thymidylate synthases (TSs). A second class of TSs, encoded by the thyX gene, is found in bacteria and a few other microbes and is especially widespread in anaerobes. TS encoded by thyX requires a flavin adenine dinucleotide pro...
Autores principales: | Conrad, John A., Ortiz-Maldonado, Mariliz, Hoppe, Samuel W., Palfey, Bruce A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical Society
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139161/ https://www.ncbi.nlm.nih.gov/pubmed/25068636 http://dx.doi.org/10.1021/bi500648n |
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