Cargando…

Gap Junction Proteins in the Blood-Brain Barrier Control Nutrient-Dependent Reactivation of Drosophila Neural Stem Cells

Neural stem cells in the adult brain exist primarily in a quiescent state but are reactivated in response to changing physiological conditions. How do stem cells sense and respond to metabolic changes? In the Drosophila CNS, quiescent neural stem cells are reactivated synchronously in response to a...

Descripción completa

Detalles Bibliográficos
Autores principales: Spéder, Pauline, Brand, Andrea H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139190/
https://www.ncbi.nlm.nih.gov/pubmed/25065772
http://dx.doi.org/10.1016/j.devcel.2014.05.021
_version_ 1782331331284303872
author Spéder, Pauline
Brand, Andrea H.
author_facet Spéder, Pauline
Brand, Andrea H.
author_sort Spéder, Pauline
collection PubMed
description Neural stem cells in the adult brain exist primarily in a quiescent state but are reactivated in response to changing physiological conditions. How do stem cells sense and respond to metabolic changes? In the Drosophila CNS, quiescent neural stem cells are reactivated synchronously in response to a nutritional stimulus. Feeding triggers insulin production by blood-brain barrier glial cells, activating the insulin/insulin-like growth factor pathway in underlying neural stem cells and stimulating their growth and proliferation. Here we show that gap junctions in the blood-brain barrier glia mediate the influence of metabolic changes on stem cell behavior, enabling glia to respond to nutritional signals and reactivate quiescent stem cells. We propose that gap junctions in the blood-brain barrier are required to translate metabolic signals into synchronized calcium pulses and insulin secretion.
format Online
Article
Text
id pubmed-4139190
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Cell Press
record_format MEDLINE/PubMed
spelling pubmed-41391902014-08-22 Gap Junction Proteins in the Blood-Brain Barrier Control Nutrient-Dependent Reactivation of Drosophila Neural Stem Cells Spéder, Pauline Brand, Andrea H. Dev Cell Article Neural stem cells in the adult brain exist primarily in a quiescent state but are reactivated in response to changing physiological conditions. How do stem cells sense and respond to metabolic changes? In the Drosophila CNS, quiescent neural stem cells are reactivated synchronously in response to a nutritional stimulus. Feeding triggers insulin production by blood-brain barrier glial cells, activating the insulin/insulin-like growth factor pathway in underlying neural stem cells and stimulating their growth and proliferation. Here we show that gap junctions in the blood-brain barrier glia mediate the influence of metabolic changes on stem cell behavior, enabling glia to respond to nutritional signals and reactivate quiescent stem cells. We propose that gap junctions in the blood-brain barrier are required to translate metabolic signals into synchronized calcium pulses and insulin secretion. Cell Press 2014-08-11 /pmc/articles/PMC4139190/ /pubmed/25065772 http://dx.doi.org/10.1016/j.devcel.2014.05.021 Text en © 2014 The Authors https://creativecommons.org/licenses/by/3.0/This work is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/) .
spellingShingle Article
Spéder, Pauline
Brand, Andrea H.
Gap Junction Proteins in the Blood-Brain Barrier Control Nutrient-Dependent Reactivation of Drosophila Neural Stem Cells
title Gap Junction Proteins in the Blood-Brain Barrier Control Nutrient-Dependent Reactivation of Drosophila Neural Stem Cells
title_full Gap Junction Proteins in the Blood-Brain Barrier Control Nutrient-Dependent Reactivation of Drosophila Neural Stem Cells
title_fullStr Gap Junction Proteins in the Blood-Brain Barrier Control Nutrient-Dependent Reactivation of Drosophila Neural Stem Cells
title_full_unstemmed Gap Junction Proteins in the Blood-Brain Barrier Control Nutrient-Dependent Reactivation of Drosophila Neural Stem Cells
title_short Gap Junction Proteins in the Blood-Brain Barrier Control Nutrient-Dependent Reactivation of Drosophila Neural Stem Cells
title_sort gap junction proteins in the blood-brain barrier control nutrient-dependent reactivation of drosophila neural stem cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139190/
https://www.ncbi.nlm.nih.gov/pubmed/25065772
http://dx.doi.org/10.1016/j.devcel.2014.05.021
work_keys_str_mv AT spederpauline gapjunctionproteinsinthebloodbrainbarriercontrolnutrientdependentreactivationofdrosophilaneuralstemcells
AT brandandreah gapjunctionproteinsinthebloodbrainbarriercontrolnutrientdependentreactivationofdrosophilaneuralstemcells