Cargando…

Postprandial Oxidative Stress and Gastrointestinal Hormones: Is There a Link?

BACKGROUND: Abnormal postprandial elevation of plasma glucose and lipids plays an important role in the pathogenesis of diabetes and strongly predicts cardiovascular mortality. In patients suffering from type 2 diabetes (T2D) postprandial state is associated with oxidative stress, cardiovascular ris...

Descripción completa

Detalles Bibliográficos
Autores principales: Malinska, Hana, Kahleova, Hana, Topolcan, Ondrej, Vrzalova, Jindra, Oliyarnyk, Olena, Kazdova, Ludmila, Belinova, Lenka, Hill, Martin, Pelikanova, Terezie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139261/
https://www.ncbi.nlm.nih.gov/pubmed/25141237
http://dx.doi.org/10.1371/journal.pone.0103565
_version_ 1782331334830587904
author Malinska, Hana
Kahleova, Hana
Topolcan, Ondrej
Vrzalova, Jindra
Oliyarnyk, Olena
Kazdova, Ludmila
Belinova, Lenka
Hill, Martin
Pelikanova, Terezie
author_facet Malinska, Hana
Kahleova, Hana
Topolcan, Ondrej
Vrzalova, Jindra
Oliyarnyk, Olena
Kazdova, Ludmila
Belinova, Lenka
Hill, Martin
Pelikanova, Terezie
author_sort Malinska, Hana
collection PubMed
description BACKGROUND: Abnormal postprandial elevation of plasma glucose and lipids plays an important role in the pathogenesis of diabetes and strongly predicts cardiovascular mortality. In patients suffering from type 2 diabetes (T2D) postprandial state is associated with oxidative stress, cardiovascular risk and, probably, with impairment of both secretion and the effect of gastrointestinal peptides. Evaluating postprandial changes of gastrointestinal hormones together with changes in oxidative stress markers may help to understand the mechanisms behind the postprandial state in diabetes as well as suggest new preventive and therapeutical strategies. METHODS: A standard meal test has been used for monitoring the postprandial concentrations of gastrointestinal hormones and oxidative stress markers in patients with T2D (n = 50) compared to healthy controls (n = 50). Blood samples were drawn 0, 30, 60, 120 and 180 minutes after the standard meal. RESULTS: Both basal and postprandial plasma concentrations of glucose and insulin proved to be significantly higher in patients with T2D, whereas plasma concentrations of ghrelin showed significantly lower values during the whole meal test. In comparison with healthy controls, both basal and postprandial concentrations of almost all other gastrointestinal hormones and lipoperoxidation were significantly increased while ascorbic acid, reduced glutathione and superoxide dismutase activity were decreased in patients with T2D. A positive relationship was found between changes in GIP and those of glucose and immunoreactive insulin in diabetic patients (p<0.001 and p<0.001, respectively) and between changes in PYY and those of glucose (p<0.01). There was a positive correlation between changes in GIP and PYY and changes in ascorbic acid in patients with T2D (p<0.05 and p<0.001, respectively). CONCLUSION/INTERPRETATION: Apart from a positive relationship of postprandial changes in GIP and PYY with changes in ascorbic acid, there was no direct link observed between gastrointestinal hormones and oxidative stress markers in diabetic patients. TRIAL REGISTRATION: ClinicalTrials.gov NCT01572402
format Online
Article
Text
id pubmed-4139261
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-41392612014-08-25 Postprandial Oxidative Stress and Gastrointestinal Hormones: Is There a Link? Malinska, Hana Kahleova, Hana Topolcan, Ondrej Vrzalova, Jindra Oliyarnyk, Olena Kazdova, Ludmila Belinova, Lenka Hill, Martin Pelikanova, Terezie PLoS One Research Article BACKGROUND: Abnormal postprandial elevation of plasma glucose and lipids plays an important role in the pathogenesis of diabetes and strongly predicts cardiovascular mortality. In patients suffering from type 2 diabetes (T2D) postprandial state is associated with oxidative stress, cardiovascular risk and, probably, with impairment of both secretion and the effect of gastrointestinal peptides. Evaluating postprandial changes of gastrointestinal hormones together with changes in oxidative stress markers may help to understand the mechanisms behind the postprandial state in diabetes as well as suggest new preventive and therapeutical strategies. METHODS: A standard meal test has been used for monitoring the postprandial concentrations of gastrointestinal hormones and oxidative stress markers in patients with T2D (n = 50) compared to healthy controls (n = 50). Blood samples were drawn 0, 30, 60, 120 and 180 minutes after the standard meal. RESULTS: Both basal and postprandial plasma concentrations of glucose and insulin proved to be significantly higher in patients with T2D, whereas plasma concentrations of ghrelin showed significantly lower values during the whole meal test. In comparison with healthy controls, both basal and postprandial concentrations of almost all other gastrointestinal hormones and lipoperoxidation were significantly increased while ascorbic acid, reduced glutathione and superoxide dismutase activity were decreased in patients with T2D. A positive relationship was found between changes in GIP and those of glucose and immunoreactive insulin in diabetic patients (p<0.001 and p<0.001, respectively) and between changes in PYY and those of glucose (p<0.01). There was a positive correlation between changes in GIP and PYY and changes in ascorbic acid in patients with T2D (p<0.05 and p<0.001, respectively). CONCLUSION/INTERPRETATION: Apart from a positive relationship of postprandial changes in GIP and PYY with changes in ascorbic acid, there was no direct link observed between gastrointestinal hormones and oxidative stress markers in diabetic patients. TRIAL REGISTRATION: ClinicalTrials.gov NCT01572402 Public Library of Science 2014-08-20 /pmc/articles/PMC4139261/ /pubmed/25141237 http://dx.doi.org/10.1371/journal.pone.0103565 Text en © 2014 Malinska et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Malinska, Hana
Kahleova, Hana
Topolcan, Ondrej
Vrzalova, Jindra
Oliyarnyk, Olena
Kazdova, Ludmila
Belinova, Lenka
Hill, Martin
Pelikanova, Terezie
Postprandial Oxidative Stress and Gastrointestinal Hormones: Is There a Link?
title Postprandial Oxidative Stress and Gastrointestinal Hormones: Is There a Link?
title_full Postprandial Oxidative Stress and Gastrointestinal Hormones: Is There a Link?
title_fullStr Postprandial Oxidative Stress and Gastrointestinal Hormones: Is There a Link?
title_full_unstemmed Postprandial Oxidative Stress and Gastrointestinal Hormones: Is There a Link?
title_short Postprandial Oxidative Stress and Gastrointestinal Hormones: Is There a Link?
title_sort postprandial oxidative stress and gastrointestinal hormones: is there a link?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139261/
https://www.ncbi.nlm.nih.gov/pubmed/25141237
http://dx.doi.org/10.1371/journal.pone.0103565
work_keys_str_mv AT malinskahana postprandialoxidativestressandgastrointestinalhormonesistherealink
AT kahleovahana postprandialoxidativestressandgastrointestinalhormonesistherealink
AT topolcanondrej postprandialoxidativestressandgastrointestinalhormonesistherealink
AT vrzalovajindra postprandialoxidativestressandgastrointestinalhormonesistherealink
AT oliyarnykolena postprandialoxidativestressandgastrointestinalhormonesistherealink
AT kazdovaludmila postprandialoxidativestressandgastrointestinalhormonesistherealink
AT belinovalenka postprandialoxidativestressandgastrointestinalhormonesistherealink
AT hillmartin postprandialoxidativestressandgastrointestinalhormonesistherealink
AT pelikanovaterezie postprandialoxidativestressandgastrointestinalhormonesistherealink