The structure and retrotransposition mechanism of LTR-retrotransposons in the asexual yeast Candida albicans

Retrotransposons constitute a major part of the genome in a number of eukaryotes. Long-terminal repeat (LTR) retrotransposons are one type of the retrotransposons. Candida albicans have 34 distinct LTR-retrotransposon families. They respectively belong to the Ty1/copia and Ty3/gypsy groups which hav...

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Detalles Bibliográficos
Autores principales: Zhang, Lulu, Yan, Lan, Jiang, Jingchen, Wang, Yan, Jiang, Yuanying, Yan, Tianhua, Cao, Yongbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139406/
https://www.ncbi.nlm.nih.gov/pubmed/25101670
http://dx.doi.org/10.4161/viru.32180
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author Zhang, Lulu
Yan, Lan
Jiang, Jingchen
Wang, Yan
Jiang, Yuanying
Yan, Tianhua
Cao, Yongbing
author_facet Zhang, Lulu
Yan, Lan
Jiang, Jingchen
Wang, Yan
Jiang, Yuanying
Yan, Tianhua
Cao, Yongbing
author_sort Zhang, Lulu
collection PubMed
description Retrotransposons constitute a major part of the genome in a number of eukaryotes. Long-terminal repeat (LTR) retrotransposons are one type of the retrotransposons. Candida albicans have 34 distinct LTR-retrotransposon families. They respectively belong to the Ty1/copia and Ty3/gypsy groups which have been extensively studied in the model yeast Saccharomyces cerevisiae. LTR-retrotransposons carry two LTRs flanking a long internal protein-coding domain, open reading frames. LTR-retrotransposons use RNA as intermediate to synthesize double-stranded DNA copies. In this article, we describe the structure feature, retrotransposition mechanism and the influence on organism diversity of LTR retrotransposons in C. albicans. We also discuss the relationship between pathogenicity and LTR retrotransposons in C. albicans.
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spelling pubmed-41394062015-08-15 The structure and retrotransposition mechanism of LTR-retrotransposons in the asexual yeast Candida albicans Zhang, Lulu Yan, Lan Jiang, Jingchen Wang, Yan Jiang, Yuanying Yan, Tianhua Cao, Yongbing Virulence Review Retrotransposons constitute a major part of the genome in a number of eukaryotes. Long-terminal repeat (LTR) retrotransposons are one type of the retrotransposons. Candida albicans have 34 distinct LTR-retrotransposon families. They respectively belong to the Ty1/copia and Ty3/gypsy groups which have been extensively studied in the model yeast Saccharomyces cerevisiae. LTR-retrotransposons carry two LTRs flanking a long internal protein-coding domain, open reading frames. LTR-retrotransposons use RNA as intermediate to synthesize double-stranded DNA copies. In this article, we describe the structure feature, retrotransposition mechanism and the influence on organism diversity of LTR retrotransposons in C. albicans. We also discuss the relationship between pathogenicity and LTR retrotransposons in C. albicans. Landes Bioscience 2014-08-15 2014-08-07 /pmc/articles/PMC4139406/ /pubmed/25101670 http://dx.doi.org/10.4161/viru.32180 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Zhang, Lulu
Yan, Lan
Jiang, Jingchen
Wang, Yan
Jiang, Yuanying
Yan, Tianhua
Cao, Yongbing
The structure and retrotransposition mechanism of LTR-retrotransposons in the asexual yeast Candida albicans
title The structure and retrotransposition mechanism of LTR-retrotransposons in the asexual yeast Candida albicans
title_full The structure and retrotransposition mechanism of LTR-retrotransposons in the asexual yeast Candida albicans
title_fullStr The structure and retrotransposition mechanism of LTR-retrotransposons in the asexual yeast Candida albicans
title_full_unstemmed The structure and retrotransposition mechanism of LTR-retrotransposons in the asexual yeast Candida albicans
title_short The structure and retrotransposition mechanism of LTR-retrotransposons in the asexual yeast Candida albicans
title_sort structure and retrotransposition mechanism of ltr-retrotransposons in the asexual yeast candida albicans
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139406/
https://www.ncbi.nlm.nih.gov/pubmed/25101670
http://dx.doi.org/10.4161/viru.32180
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