The evolution of enzyme function in the isomerases

The advent of computational approaches to measure functional similarity between enzymes adds a new dimension to existing evolutionary studies based on sequence and structure. This paper reviews research efforts aiming to understand the evolution of enzyme function in superfamilies, presenting a nove...

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Detalles Bibliográficos
Autores principales: Martinez Cuesta, Sergio, Furnham, Nicholas, Rahman, Syed Asad, Sillitoe, Ian, Thornton, Janet M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139412/
https://www.ncbi.nlm.nih.gov/pubmed/25000289
http://dx.doi.org/10.1016/j.sbi.2014.06.002
Descripción
Sumario:The advent of computational approaches to measure functional similarity between enzymes adds a new dimension to existing evolutionary studies based on sequence and structure. This paper reviews research efforts aiming to understand the evolution of enzyme function in superfamilies, presenting a novel strategy to provide an overview of the evolution of enzymes belonging to an individual EC class, using the isomerases as an exemplar.

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