The evolution of enzyme function in the isomerases

The advent of computational approaches to measure functional similarity between enzymes adds a new dimension to existing evolutionary studies based on sequence and structure. This paper reviews research efforts aiming to understand the evolution of enzyme function in superfamilies, presenting a nove...

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Detalles Bibliográficos
Autores principales: Martinez Cuesta, Sergio, Furnham, Nicholas, Rahman, Syed Asad, Sillitoe, Ian, Thornton, Janet M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139412/
https://www.ncbi.nlm.nih.gov/pubmed/25000289
http://dx.doi.org/10.1016/j.sbi.2014.06.002
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author Martinez Cuesta, Sergio
Furnham, Nicholas
Rahman, Syed Asad
Sillitoe, Ian
Thornton, Janet M
author_facet Martinez Cuesta, Sergio
Furnham, Nicholas
Rahman, Syed Asad
Sillitoe, Ian
Thornton, Janet M
author_sort Martinez Cuesta, Sergio
collection PubMed
description The advent of computational approaches to measure functional similarity between enzymes adds a new dimension to existing evolutionary studies based on sequence and structure. This paper reviews research efforts aiming to understand the evolution of enzyme function in superfamilies, presenting a novel strategy to provide an overview of the evolution of enzymes belonging to an individual EC class, using the isomerases as an exemplar.
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spelling pubmed-41394122014-08-22 The evolution of enzyme function in the isomerases Martinez Cuesta, Sergio Furnham, Nicholas Rahman, Syed Asad Sillitoe, Ian Thornton, Janet M Curr Opin Struct Biol Article The advent of computational approaches to measure functional similarity between enzymes adds a new dimension to existing evolutionary studies based on sequence and structure. This paper reviews research efforts aiming to understand the evolution of enzyme function in superfamilies, presenting a novel strategy to provide an overview of the evolution of enzymes belonging to an individual EC class, using the isomerases as an exemplar. Elsevier Science 2014-06 /pmc/articles/PMC4139412/ /pubmed/25000289 http://dx.doi.org/10.1016/j.sbi.2014.06.002 Text en © 2014 The Authors https://creativecommons.org/licenses/by/3.0/This work is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/) .
spellingShingle Article
Martinez Cuesta, Sergio
Furnham, Nicholas
Rahman, Syed Asad
Sillitoe, Ian
Thornton, Janet M
The evolution of enzyme function in the isomerases
title The evolution of enzyme function in the isomerases
title_full The evolution of enzyme function in the isomerases
title_fullStr The evolution of enzyme function in the isomerases
title_full_unstemmed The evolution of enzyme function in the isomerases
title_short The evolution of enzyme function in the isomerases
title_sort evolution of enzyme function in the isomerases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139412/
https://www.ncbi.nlm.nih.gov/pubmed/25000289
http://dx.doi.org/10.1016/j.sbi.2014.06.002
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