Cell-intrinsic lysosomal lipolysis is essential for macrophage alternative activation

Alternative (M2) macrophage activation driven through interleukin 4 receptor α (IL-4Rα) is important for immunity to parasites, wound healing, the prevention of atherosclerosis and metabolic homeostasis. M2 polarization is dependent on fatty acid oxidation (FAO), but the source of fatty acids to sup...

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Detalles Bibliográficos
Autores principales: Huang, Stanley Ching-Cheng, Everts, Bart, Ivanova, Yulia, O'Sullivan, David, Nascimento, Marcia, Smith, Amber M., Beatty, Wandy, Love-Gregory, Latisha, Lam, Wing Y., O'Neill, Christina M., Yan, Cong, Du, Hong, Abumrad, Nada A., Urban, Joseph F., Artyomov, Maxim N., Pearce, Erika L., Pearce, Edward J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139419/
https://www.ncbi.nlm.nih.gov/pubmed/25086775
http://dx.doi.org/10.1038/ni.2956

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