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Impact of Serum Chemerin Levels on Liver Functional Reserves and Platelet Counts in Patients with Hepatocellular Carcinoma

Obesity-related metabolic abnormalities, including adipokine imbalance and chronic inflammation, are involved in liver carcinogenesis. Chemerin, a novel adipokine, plays a critical role in adipogenesis, energy metabolism, and inflammation. We evaluated the impact of serum chemerin levels on liver fu...

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Autores principales: Imai, Kenji, Takai, Koji, Hanai, Tatsunori, Shiraki, Makoto, Suzuki, Yusuke, Hayashi, Hideki, Naiki, Takafumi, Nishigaki, Youichi, Tomita, Eiichi, Shimizu, Masahito, Moriwaki, Hisataka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139783/
https://www.ncbi.nlm.nih.gov/pubmed/24968270
http://dx.doi.org/10.3390/ijms150711294
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author Imai, Kenji
Takai, Koji
Hanai, Tatsunori
Shiraki, Makoto
Suzuki, Yusuke
Hayashi, Hideki
Naiki, Takafumi
Nishigaki, Youichi
Tomita, Eiichi
Shimizu, Masahito
Moriwaki, Hisataka
author_facet Imai, Kenji
Takai, Koji
Hanai, Tatsunori
Shiraki, Makoto
Suzuki, Yusuke
Hayashi, Hideki
Naiki, Takafumi
Nishigaki, Youichi
Tomita, Eiichi
Shimizu, Masahito
Moriwaki, Hisataka
author_sort Imai, Kenji
collection PubMed
description Obesity-related metabolic abnormalities, including adipokine imbalance and chronic inflammation, are involved in liver carcinogenesis. Chemerin, a novel adipokine, plays a critical role in adipogenesis, energy metabolism, and inflammation. We evaluated the impact of serum chemerin levels on liver functional reserves in hepatocellular carcinoma (HCC) patients and on the recurrence and prognosis of HCC. This study included 44 patients with any stage of HCC who underwent curative treatment at Gifu Municipal Hospital (Gifu, Japan) between 2006 and 2007. Recurrence-free survival and overall survival were estimated using the Kaplan-Meier method. Serum albumin levels (Pearson’s correlation coefficient; r = 0.3110, p = 0.0399), platelet counts (r = 0.4159, p = 0.0050), and prothrombin times (r = 0.3775, p = 0.0115) were significantly correlated with serum chemerin levels in patients with HCC, and they were inversely correlated with Child-Pugh scores (r = −0.3732, p = 0.0126), serum alanine aminotransferase levels (r = −0.3864, p = 0.0105), and total bilirubin levels (r = −0.4023, p = 0.0068). Among these variables, a multiple comparison test identified that platelet counts and total bilirubin levels were associated with serum chemerin levels (p < 0.0083). No significant correlation was found between serum chemerin levels and recurrence-free survival (p = 0.3691) or overall survival (p = 0.7916). In HCC patients, serum chemerin concentrations were correlated with liver functional reserves and platelet counts, but not with recurrence or prognosis.
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spelling pubmed-41397832014-08-21 Impact of Serum Chemerin Levels on Liver Functional Reserves and Platelet Counts in Patients with Hepatocellular Carcinoma Imai, Kenji Takai, Koji Hanai, Tatsunori Shiraki, Makoto Suzuki, Yusuke Hayashi, Hideki Naiki, Takafumi Nishigaki, Youichi Tomita, Eiichi Shimizu, Masahito Moriwaki, Hisataka Int J Mol Sci Article Obesity-related metabolic abnormalities, including adipokine imbalance and chronic inflammation, are involved in liver carcinogenesis. Chemerin, a novel adipokine, plays a critical role in adipogenesis, energy metabolism, and inflammation. We evaluated the impact of serum chemerin levels on liver functional reserves in hepatocellular carcinoma (HCC) patients and on the recurrence and prognosis of HCC. This study included 44 patients with any stage of HCC who underwent curative treatment at Gifu Municipal Hospital (Gifu, Japan) between 2006 and 2007. Recurrence-free survival and overall survival were estimated using the Kaplan-Meier method. Serum albumin levels (Pearson’s correlation coefficient; r = 0.3110, p = 0.0399), platelet counts (r = 0.4159, p = 0.0050), and prothrombin times (r = 0.3775, p = 0.0115) were significantly correlated with serum chemerin levels in patients with HCC, and they were inversely correlated with Child-Pugh scores (r = −0.3732, p = 0.0126), serum alanine aminotransferase levels (r = −0.3864, p = 0.0105), and total bilirubin levels (r = −0.4023, p = 0.0068). Among these variables, a multiple comparison test identified that platelet counts and total bilirubin levels were associated with serum chemerin levels (p < 0.0083). No significant correlation was found between serum chemerin levels and recurrence-free survival (p = 0.3691) or overall survival (p = 0.7916). In HCC patients, serum chemerin concentrations were correlated with liver functional reserves and platelet counts, but not with recurrence or prognosis. MDPI 2014-06-25 /pmc/articles/PMC4139783/ /pubmed/24968270 http://dx.doi.org/10.3390/ijms150711294 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Imai, Kenji
Takai, Koji
Hanai, Tatsunori
Shiraki, Makoto
Suzuki, Yusuke
Hayashi, Hideki
Naiki, Takafumi
Nishigaki, Youichi
Tomita, Eiichi
Shimizu, Masahito
Moriwaki, Hisataka
Impact of Serum Chemerin Levels on Liver Functional Reserves and Platelet Counts in Patients with Hepatocellular Carcinoma
title Impact of Serum Chemerin Levels on Liver Functional Reserves and Platelet Counts in Patients with Hepatocellular Carcinoma
title_full Impact of Serum Chemerin Levels on Liver Functional Reserves and Platelet Counts in Patients with Hepatocellular Carcinoma
title_fullStr Impact of Serum Chemerin Levels on Liver Functional Reserves and Platelet Counts in Patients with Hepatocellular Carcinoma
title_full_unstemmed Impact of Serum Chemerin Levels on Liver Functional Reserves and Platelet Counts in Patients with Hepatocellular Carcinoma
title_short Impact of Serum Chemerin Levels on Liver Functional Reserves and Platelet Counts in Patients with Hepatocellular Carcinoma
title_sort impact of serum chemerin levels on liver functional reserves and platelet counts in patients with hepatocellular carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139783/
https://www.ncbi.nlm.nih.gov/pubmed/24968270
http://dx.doi.org/10.3390/ijms150711294
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