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Biochemical Alterations during the Obese-Aging Process in Female and Male Monosodium Glutamate (MSG)-Treated Mice

Obesity, from children to the elderly, has increased in the world at an alarming rate over the past three decades, implying long-term detrimental consequences for individual’s health. Obesity and aging are known to be risk factors for metabolic disorder development, insulin resistance and inflammati...

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Autores principales: Hernández-Bautista, René J., Alarcón-Aguilar, Francisco J., Escobar-Villanueva, María Del C., Almanza-Pérez, Julio C., Merino-Aguilar, Héctor, Konigsberg Fainstein, Mina, López-Diazguerrero, Norma E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139794/
https://www.ncbi.nlm.nih.gov/pubmed/24979131
http://dx.doi.org/10.3390/ijms150711473
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author Hernández-Bautista, René J.
Alarcón-Aguilar, Francisco J.
Escobar-Villanueva, María Del C.
Almanza-Pérez, Julio C.
Merino-Aguilar, Héctor
Konigsberg Fainstein, Mina
López-Diazguerrero, Norma E.
author_facet Hernández-Bautista, René J.
Alarcón-Aguilar, Francisco J.
Escobar-Villanueva, María Del C.
Almanza-Pérez, Julio C.
Merino-Aguilar, Héctor
Konigsberg Fainstein, Mina
López-Diazguerrero, Norma E.
author_sort Hernández-Bautista, René J.
collection PubMed
description Obesity, from children to the elderly, has increased in the world at an alarming rate over the past three decades, implying long-term detrimental consequences for individual’s health. Obesity and aging are known to be risk factors for metabolic disorder development, insulin resistance and inflammation, but their relationship is not fully understood. Prevention and appropriate therapies for metabolic disorders and physical disabilities in older adults have become a major public health challenge. Hence, the aim of this study was to evaluate inflammation markers, biochemical parameters and glucose homeostasis during the obese-aging process, to understand the relationship between obesity and health span during the lifetime. In order to do this, the monosodium glutamate (MSG) obesity mice model was used, and data were evaluated at 4, 8, 12, 16 and 20 months in both female and male mice. Our results showed that obesity was a major factor contributing to premature alterations in MSG-treated mice metabolism; however, at older ages, obesity effects were attenuated and MSG-mice became more similar to normal mice. At a younger age (four months old), the Lee index, triglycerides, total cholesterol, TNF-α and transaminases levels increased; while adiponectin decreased and glucose tolerance and insulin sensitivity levels were remarkably altered. However, from 16 months old-on, the Lee index and TNF-α levels diminished significantly, while adiponectin increased, and glucose and insulin homeostasis was recovered. In summary, MSG-treated obese mice showed metabolic changes and differential susceptibility by gender throughout life and during the aging process. Understanding metabolic differences between genders during the lifespan will allow the discovery of specific preventive treatment strategies for chronic diseases and functional decline.
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spelling pubmed-41397942014-08-21 Biochemical Alterations during the Obese-Aging Process in Female and Male Monosodium Glutamate (MSG)-Treated Mice Hernández-Bautista, René J. Alarcón-Aguilar, Francisco J. Escobar-Villanueva, María Del C. Almanza-Pérez, Julio C. Merino-Aguilar, Héctor Konigsberg Fainstein, Mina López-Diazguerrero, Norma E. Int J Mol Sci Article Obesity, from children to the elderly, has increased in the world at an alarming rate over the past three decades, implying long-term detrimental consequences for individual’s health. Obesity and aging are known to be risk factors for metabolic disorder development, insulin resistance and inflammation, but their relationship is not fully understood. Prevention and appropriate therapies for metabolic disorders and physical disabilities in older adults have become a major public health challenge. Hence, the aim of this study was to evaluate inflammation markers, biochemical parameters and glucose homeostasis during the obese-aging process, to understand the relationship between obesity and health span during the lifetime. In order to do this, the monosodium glutamate (MSG) obesity mice model was used, and data were evaluated at 4, 8, 12, 16 and 20 months in both female and male mice. Our results showed that obesity was a major factor contributing to premature alterations in MSG-treated mice metabolism; however, at older ages, obesity effects were attenuated and MSG-mice became more similar to normal mice. At a younger age (four months old), the Lee index, triglycerides, total cholesterol, TNF-α and transaminases levels increased; while adiponectin decreased and glucose tolerance and insulin sensitivity levels were remarkably altered. However, from 16 months old-on, the Lee index and TNF-α levels diminished significantly, while adiponectin increased, and glucose and insulin homeostasis was recovered. In summary, MSG-treated obese mice showed metabolic changes and differential susceptibility by gender throughout life and during the aging process. Understanding metabolic differences between genders during the lifespan will allow the discovery of specific preventive treatment strategies for chronic diseases and functional decline. MDPI 2014-06-27 /pmc/articles/PMC4139794/ /pubmed/24979131 http://dx.doi.org/10.3390/ijms150711473 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Hernández-Bautista, René J.
Alarcón-Aguilar, Francisco J.
Escobar-Villanueva, María Del C.
Almanza-Pérez, Julio C.
Merino-Aguilar, Héctor
Konigsberg Fainstein, Mina
López-Diazguerrero, Norma E.
Biochemical Alterations during the Obese-Aging Process in Female and Male Monosodium Glutamate (MSG)-Treated Mice
title Biochemical Alterations during the Obese-Aging Process in Female and Male Monosodium Glutamate (MSG)-Treated Mice
title_full Biochemical Alterations during the Obese-Aging Process in Female and Male Monosodium Glutamate (MSG)-Treated Mice
title_fullStr Biochemical Alterations during the Obese-Aging Process in Female and Male Monosodium Glutamate (MSG)-Treated Mice
title_full_unstemmed Biochemical Alterations during the Obese-Aging Process in Female and Male Monosodium Glutamate (MSG)-Treated Mice
title_short Biochemical Alterations during the Obese-Aging Process in Female and Male Monosodium Glutamate (MSG)-Treated Mice
title_sort biochemical alterations during the obese-aging process in female and male monosodium glutamate (msg)-treated mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139794/
https://www.ncbi.nlm.nih.gov/pubmed/24979131
http://dx.doi.org/10.3390/ijms150711473
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