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Supraspliceosomes at Defined Functional States Portray the Pre-Assembled Nature of the Pre-mRNA Processing Machine in the Cell Nucleus

When isolated from mammalian cell nuclei, all nuclear pre-mRNAs are packaged in multi-subunit large ribonucleoprotein complexes—supraspliceosomes—composed of four native spliceosomes interconnected by the pre-mRNA. Supraspliceosomes contain all five spliceosomal U snRNPs, together with other splicin...

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Detalles Bibliográficos
Autores principales:	Kotzer-Nevo, Hani, de Lima Alves, Flavia, Rappsilber, Juri, Sperling, Joseph, Sperling, Ruth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139805/ https://www.ncbi.nlm.nih.gov/pubmed/24983480 http://dx.doi.org/10.3390/ijms150711637

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