Cargando…

Paeonol Suppresses Chondrosarcoma Metastasis through Up-Regulation of miR-141 by Modulating PKCδ and c-Src Signaling Pathway

Chondrosarcoma, a primary malignant bone cancer, has potential for local invasion and distant metastasis, especially to the lungs. Patients diagnosed with it show poor prognosis. Paeonol (2'-hydroxy-4'-methoxyacetophenone), the main active compound of traditional Chinese remedy Paeonia lac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Horng, Chi-Ting, Shieh, Po-Chuen, Tan, Tzu-Wei, Yang, Wei-Hung, Tang, Chih-Hsin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139812/ https://www.ncbi.nlm.nih.gov/pubmed/24992595 http://dx.doi.org/10.3390/ijms150711760

Ejemplares similares

Berberine Reduces the Metastasis of Chondrosarcoma by Modulating the αvβ3 Integrin and the PKCδ, c-Src, and AP-1 Signaling Pathways
por: Wu, Chi-Ming, et al.
Publicado: (2013)

Thrombin Promotes Matrix Metalloproteinase-13 Expression through the PKCδ/c-Src/EGFR/PI3K/Akt/AP-1 Signaling Pathway in Human Chondrocytes
por: Huang, Chun-Yin, et al.
Publicado: (2013)

Src, PKCα, and PKCδ are required for αvβ3 integrin-mediated metastatic melanoma invasion
por: Putnam, Andrew J, et al.
Publicado: (2009)

Resistin promotes tumor metastasis by down-regulation of miR-519d through the AMPK/p38 signaling pathway in human chondrosarcoma cells
por: Tsai, Chun-Hao, et al.
Publicado: (2014)

Global Phosphotyrosine Proteomics Identifies PKCδ as a Marker of Responsiveness to Src Inhibition in Colorectal Cancer
por: McKinley, Eliot T., et al.
Publicado: (2013)

PKCα and PKCδ: Friends and Rivals
por: Black, Jennifer D., et al.
Publicado: (2022)

Correction: Resistin promotes tumor metastasis by down-regulation of miR-519d through the AMPK/p38 signaling pathway in human chondrosarcoma cells
por: Tsai, Chun-Hao, et al.
Publicado: (2018)

PKCδ-mediated SGLT1 upregulation confers the acquired resistance of NSCLC to EGFR TKIs
por: Chen, Chia-Hung, et al.
Publicado: (2021)

Nerve growth factor promotes lysyl oxidase-dependent chondrosarcoma cell metastasis by suppressing miR-149-5p synthesis
por: Tzeng, Huey-En, et al.
Publicado: (2021)

Leptin promotes VEGF-C production and induces lymphangiogenesis by suppressing miR-27b in human chondrosarcoma cells
por: Yang, Wei-Hung, et al.
Publicado: (2016)

miR-486 suppresses the development of osteosarcoma by regulating PKC-δ pathway
por: He, Ming, et al.
Publicado: (2017)

miR-486 suppresses the development of osteosarcoma by regulating PKC-δ pathway
por: He, Ming, et al.
Publicado: (2023)

Differential Roles of the PKC Novel Isoforms, PKCδ and PKCε, in Mouse and Human Platelets
por: Pears, Catherine J., et al.
Publicado: (2008)

PKCδ Blues for the β-Cell
por: Schmitz-Peiffer, Carsten, et al.
Publicado: (2010)

CCL5 promotes VEGF-dependent angiogenesis by down-regulating miR-200b through PI3K/Akt signaling pathway in human chondrosarcoma cells
por: Liu, Guan-Ting, et al.
Publicado: (2014)

The mir-423-5p/MMP-2 Axis Regulates the Nerve Growth Factor-Induced Promotion of Chondrosarcoma Metastasis
por: Tzeng, Huey-En, et al.
Publicado: (2021)

Overexpressed PKCδ Downregulates the Expression of PKCα in B16F10 Melanoma: Induction of Apoptosis by PKCδ via Ceramide Generation
por: Halder, Kuntal, et al.
Publicado: (2014)

Thrombospondin‐2 stimulates MMP‐9 production and promotes osteosarcoma metastasis via the PLC, PKC, c‐Src and NF‐κB activation
por: Liu, Ju‐Fang, et al.
Publicado: (2020)

Sphingosine‐1‐phosphate suppresses chondrosarcoma metastasis by upregulation of tissue inhibitor of metalloproteinase 3 through suppressing miR‐101 expression
por: Tsai, Chun‐Hao, et al.
Publicado: (2017)

Targeting the histone demethylase PHF8-mediated PKCα-Src-PTEN axis in HER2-negative gastric cancer
por: Tseng, Lin-Lu, et al.
Publicado: (2020)

A review on therapeutical potential of paeonol in atherosclerosis
por: Yu, Wei, et al.
Publicado: (2022)

Pharmacokinetics, Tissue Distribution and Excretion of Paeonol and Its Major Metabolites in Rats Provide a Further Insight Into Paeonol Effectiveness
por: Hu, Xintong, et al.
Publicado: (2020)

B7-H4 expression is upregulated by PKCδ activation and contributes to PKCδ-induced cell motility in colorectal cancer
por: Zhou, Bin, et al.
Publicado: (2022)

Thyroid metastasis from chondrosarcoma
por: Wu, Zhi-Hong, et al.
Publicado: (2019)

WISP-3 inhibition of miR-452 promotes VEGF-A expression in chondrosarcoma cells and induces endothelial progenitor cells angiogenesis
por: Lin, Chih-Yang, et al.
Publicado: (2017)

Single Ethanol Withdrawal Regulates Extrasynaptic δ-GABA(A) Receptors Via PKCδ Activation
por: Chen, Juan, et al.
Publicado: (2018)

Novel small molecule inhibiting CDCP1‐PKCδ pathway reduces tumor metastasis and proliferation
por: Nakashima, Katsuhiko, et al.
Publicado: (2017)

PKCδ regulates the vascular biology in diabetic atherosclerosis
por: Qin, Peiliang, et al.
Publicado: (2023)

PKCδ deficiency inhibits fetal development and is associated with heart elastic fiber hyperplasia and lung inflammation in adult PKCδ knockout mice
por: Niino, Yuko S., et al.
Publicado: (2021)

BMP-7 Enhances Cell Migration and αvβ3 Integrin Expression via a c-Src-Dependent Pathway in Human Chondrosarcoma Cells
por: Chen, Jui-Chieh, et al.
Publicado: (2014)

Prevention of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice by Paeonol
por: Liu, Meng-Han, et al.
Publicado: (2017)

Effects of Paeonol on Anti-Neuroinflammatory Responses in Microglial Cells
por: Lin, Chingju, et al.
Publicado: (2015)

Vertebral body chondrosarcoma with metastasis to the scalp
por: Fukuda, Aya, et al.
Publicado: (2018)

Exosomal miR-141-3p regulates osteoblast activity to promote the osteoblastic metastasis of prostate cancer
por: Ye, Yun, et al.
Publicado: (2017)

Paeonol protects against doxorubicin-induced cardiotoxicity by promoting Mfn2-mediated mitochondrial fusion through activating the PKCε-Stat3 pathway
por: Ding, Mingge, et al.
Publicado: (2022)

A Rare Case Report of Mesenchymal Chondrosarcoma with Pancreatic Metastasis
por: Chen, Jian-Jiun, et al.
Publicado: (2022)

Role of PKCδ in Insulin Sensitivity and Skeletal Muscle Metabolism
por: Li, Mengyao, et al.
Publicado: (2015)

Control of nuclear-cytoplasmic shuttling of Ankrd54 by PKCδ
por: Samuels, Amy L, et al.
Publicado: (2017)

Brain-derived neurotrophic factor promotes VEGF-C-dependent lymphangiogenesis by suppressing miR-624-3p in human chondrosarcoma cells
por: Lin, Chih-Yang, et al.
Publicado: (2017)

Paeonol Attenuates Cigarette Smoke-Induced Lung Inflammation by Inhibiting ROS-Sensitive Inflammatory Signaling
por: Liu, Meng-Han, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_8p2m6i7djbc8b8p60gb72qrshq