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Bioactive Coatings for Orthopaedic Implants—Recent Trends in Development of Implant Coatings
Joint replacement is a major orthopaedic procedure used to treat joint osteoarthritis. Aseptic loosening and infection are the two most significant causes of prosthetic implant failure. The ideal implant should be able to promote osteointegration, deter bacterial adhesion and minimize prosthetic inf...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139820/ https://www.ncbi.nlm.nih.gov/pubmed/25000263 http://dx.doi.org/10.3390/ijms150711878 |
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author | Zhang, Bill G. X. Myers, Damian E. Wallace, Gordon G. Brandt, Milan Choong, Peter F. M. |
author_facet | Zhang, Bill G. X. Myers, Damian E. Wallace, Gordon G. Brandt, Milan Choong, Peter F. M. |
author_sort | Zhang, Bill G. X. |
collection | PubMed |
description | Joint replacement is a major orthopaedic procedure used to treat joint osteoarthritis. Aseptic loosening and infection are the two most significant causes of prosthetic implant failure. The ideal implant should be able to promote osteointegration, deter bacterial adhesion and minimize prosthetic infection. Recent developments in material science and cell biology have seen the development of new orthopaedic implant coatings to address these issues. Coatings consisting of bioceramics, extracellular matrix proteins, biological peptides or growth factors impart bioactivity and biocompatibility to the metallic surface of conventional orthopaedic prosthesis that promote bone ingrowth and differentiation of stem cells into osteoblasts leading to enhanced osteointegration of the implant. Furthermore, coatings such as silver, nitric oxide, antibiotics, antiseptics and antimicrobial peptides with anti-microbial properties have also been developed, which show promise in reducing bacterial adhesion and prosthetic infections. This review summarizes some of the recent developments in coatings for orthopaedic implants. |
format | Online Article Text |
id | pubmed-4139820 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-41398202014-08-21 Bioactive Coatings for Orthopaedic Implants—Recent Trends in Development of Implant Coatings Zhang, Bill G. X. Myers, Damian E. Wallace, Gordon G. Brandt, Milan Choong, Peter F. M. Int J Mol Sci Review Joint replacement is a major orthopaedic procedure used to treat joint osteoarthritis. Aseptic loosening and infection are the two most significant causes of prosthetic implant failure. The ideal implant should be able to promote osteointegration, deter bacterial adhesion and minimize prosthetic infection. Recent developments in material science and cell biology have seen the development of new orthopaedic implant coatings to address these issues. Coatings consisting of bioceramics, extracellular matrix proteins, biological peptides or growth factors impart bioactivity and biocompatibility to the metallic surface of conventional orthopaedic prosthesis that promote bone ingrowth and differentiation of stem cells into osteoblasts leading to enhanced osteointegration of the implant. Furthermore, coatings such as silver, nitric oxide, antibiotics, antiseptics and antimicrobial peptides with anti-microbial properties have also been developed, which show promise in reducing bacterial adhesion and prosthetic infections. This review summarizes some of the recent developments in coatings for orthopaedic implants. MDPI 2014-07-04 /pmc/articles/PMC4139820/ /pubmed/25000263 http://dx.doi.org/10.3390/ijms150711878 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Zhang, Bill G. X. Myers, Damian E. Wallace, Gordon G. Brandt, Milan Choong, Peter F. M. Bioactive Coatings for Orthopaedic Implants—Recent Trends in Development of Implant Coatings |
title | Bioactive Coatings for Orthopaedic Implants—Recent Trends in Development of Implant Coatings |
title_full | Bioactive Coatings for Orthopaedic Implants—Recent Trends in Development of Implant Coatings |
title_fullStr | Bioactive Coatings for Orthopaedic Implants—Recent Trends in Development of Implant Coatings |
title_full_unstemmed | Bioactive Coatings for Orthopaedic Implants—Recent Trends in Development of Implant Coatings |
title_short | Bioactive Coatings for Orthopaedic Implants—Recent Trends in Development of Implant Coatings |
title_sort | bioactive coatings for orthopaedic implants—recent trends in development of implant coatings |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139820/ https://www.ncbi.nlm.nih.gov/pubmed/25000263 http://dx.doi.org/10.3390/ijms150711878 |
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