Cargando…

Radiosensitization of Human Leukemic HL-60 Cells by ATR Kinase Inhibitor (VE-821): Phosphoproteomic Analysis

DNA damaging agents such as ionizing radiation or chemotherapy are frequently used in oncology. DNA damage response (DDR)—triggered by radiation-induced double strand breaks—is orchestrated mainly by three Phosphatidylinositol 3-kinase-related kinases (PIKKs): Ataxia teleangiectasia mutated (ATM), D...

Descripción completa

Detalles Bibliográficos
Autores principales:	Šalovská, Barbora, Fabrik, Ivo, Ďurišová, Kamila, Link, Marek, Vávrová, Jiřina, Řezáčová, Martina, Tichý, Aleš
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139827/ https://www.ncbi.nlm.nih.gov/pubmed/25003641 http://dx.doi.org/10.3390/ijms150712007

Ejemplares similares

Radio-sensitizing effects of VE-821 and beyond: Distinct phosphoproteomic and metabolomic changes after ATR inhibition in irradiated MOLT-4 cells
por: Šalovská, Barbora, et al.
Publicado: (2018)

VE-821, an ATR inhibitor, causes radiosensitization in human tumor cells irradiated with high LET radiation
por: Fujisawa, Hiroshi, et al.
Publicado: (2015)

The ATR Inhibitor VE-821 Enhances the Radiosensitivity and Suppresses DNA Repair Mechanisms of Human Chondrosarcoma Cells
por: Lohberger, Birgit, et al.
Publicado: (2023)

The ATR inhibitor VE-821 increases the sensitivity of gastric cancer cells to cisplatin
por: Su, Haochen, et al.
Publicado: (2023)

Phosphoproteomics of ATR signaling in mouse testes
por: Sims, Jennie R, et al.
Publicado: (2022)

Phosphoproteomics of cAMP signaling of Bordetella adenylate cyclase toxin in mouse dendritic cells
por: Novák, Jakub, et al.
Publicado: (2017)

A basic phosphoproteomic-DIA workflow integrating precise quantification of phosphosites in systems biology
por: Di, Yi, et al.
Publicado: (2023)

Distinct cellular responses to replication stress leading to apoptosis or senescence
por: Lukášová, Emilie, et al.
Publicado: (2019)

Quantitative phosphoproteomics reveals mitotic function of the ATR activator ETAA1
por: Bass, Thomas E., et al.
Publicado: (2019)

Quantification of cellular protein and redox imbalance using SILAC-iodoTMT methodology
por: Vajrychova, Marie, et al.
Publicado: (2019)

An optogenetic-phosphoproteomic study reveals dynamic Akt1 signaling profiles in endothelial cells
por: Zhou, Wenping, et al.
Publicado: (2023)

Peroxiredoxin 6 protects irradiated cells from oxidative stress and shapes their senescence-associated cytokine landscape
por: Salovska, Barbora, et al.
Publicado: (2021)

Phosphoproteomic analysis of metformin signaling in colorectal cancer cells elucidates mechanism of action and potential therapeutic opportunities
por: Salovska, Barbora, et al.
Publicado: (2023)

Radiosensitization by Kinase Inhibition Revealed by Phosphoproteomic Analysis of Pancreatic Cancer Cells
por: Wiechmann, Svenja, et al.
Publicado: (2020)

Genome-wide co-occupancy of AML1-ETO and N-CoR defines the t(8;21) AML signature in leukemic cells
por: Trombly, Daniel J, et al.
Publicado: (2015)

pH homeostasis in promyelocytic leukemic HL60 cells
Publicado: (1988)

Effective Radiosensitization of Bladder Cancer Cells by Pharmacological Inhibition of DNA-PK and ATR
por: Chughtai, Ahmed Ali, et al.
Publicado: (2022)

Immunocytochemistry of Apoptosis Induced by Bromodeoxyuridine in Human Leukemic HL‐60 Cells
por: Kondo, Kazumasa, et al.
Publicado: (1997)

Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation
por: Fokas, E, et al.
Publicado: (2012)

VE-822 mediated inhibition of ATR signaling sensitizes chondrosarcoma to cisplatin via reversion of the DNA damage response
por: Liang, Xiao, et al.
Publicado: (2019)

Combined ATR and DNA-PK Inhibition Radiosensitizes Tumor Cells Independently of Their p53 Status
por: Hafsi, Hind, et al.
Publicado: (2018)

Combined Treatment with Low Concentrations of Decitabine and SAHA Causes Cell Death in Leukemic Cell Lines but Not in Normal Peripheral Blood Lymphocytes
por: Brodská, Barbora, et al.
Publicado: (2013)

Sonata for arpeggione and piano in A minor, d. 821 /
por: Schubert, Franz, 1797-1828
Publicado: (1985)

A new inducible model for t(8;21) AML
por: Mulloy, James C
Publicado: (2013)

Functional changes in human leukemic cell line HL-60. A model for myeloid differentiation
por: Newburger, PE, et al.
Publicado: (1979)

Antileukemic Potential of Momordica charantia Seed Extracts on Human Myeloid Leukemic HL60 Cells
por: Soundararajan, Ramani, et al.
Publicado: (2012)

Retinoic Acid Therapy Resistance Progresses from Unilineage to Bilineage in HL-60 Leukemic Blasts
por: Jensen, Holly A., et al.
Publicado: (2014)

HOXB1 restored expression promotes apoptosis and differentiation in the HL60 leukemic cell line
por: Petrini, Marina, et al.
Publicado: (2013)

Anti-Leukemic Activity of Brassica-Derived Bioactive Compounds in HL-60 Myeloid Leukemia Cells
por: Núñez-Sánchez, María Ángeles, et al.
Publicado: (2022)

They've said it, they've done it
por: Association
Publicado: (2007)

Inhibition of DNA-PKcs enhances radiosensitivity and increases the levels of ATM and ATR in NSCLC cells exposed to carbon ion irradiation
por: YANG, LINA, et al.
Publicado: (2015)

Risk Factors for Trauma-Related Eviscerations: Analysis of 821 Cases
por: Jiang, Zhaoxin, et al.
Publicado: (2019)

The Effects of Purified Artemia Extract Proteins on Proliferation, Differentiation and Apoptosis of Human Leukemic HL-60 Cells
por: Deezagi, Abdolkhaleg, et al.
Publicado: (2016)

JAK inhibitors suppress t(8;21) fusion protein-induced leukemia
por: Lo, Miao-Chia, et al.
Publicado: (2013)

我如何治疗t（8；21）急性髓系白血病
Publicado: (2017)

821. Portable Medical Equipment Disinfection: How often does it occur?
por: Jinadatha, Chetan, et al.
Publicado: (2020)

821. Positive Follow-Up Blood Culture in Candidemia and Ocular Involvement
por: Iqbal, Hamail, et al.
Publicado: (2023)

Glycyrrhetinic Acid Induces Apoptosis in Leukemic HL60 Cells Through Upregulating of CD95/ CD178
por: Pirzadeh, Sara, et al.
Publicado: (2014)

Quantitative Phosphoproteomics of the Ataxia Telangiectasia-Mutated (ATM) and Ataxia Telangiectasia-Mutated and Rad3-related (ATR) Dependent DNA Damage Response in Arabidopsis thaliana
por: Roitinger, Elisabeth, et al.
Publicado: (2015)

Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA
por: Menolfi, Demis, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_bh9tc700teih27cg9a3uto1mlm