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Melatonin Promotes Superovulation in Sika Deer (Cervus nippon)

In this study, the effects of melatonin (MT) on superovulation and reproductive hormones (melatonin, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and PRL) were investigated in female sika deer. Different doses (40 or 80 mg/animal) of melatonin were subcutaneously implanted into deer...

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Autores principales: Wang, Liang, Zhuo, Zhi-Yong, Shi, Wen-Qing, Tan, Dun-Xian, Gao, Chao, Tian, Xiu-Zhi, Zhang, Lu, Zhou, Guang-Bin, Zhu, Shi-En, Yun, Peng, Liu, Guo-Shi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139832/
https://www.ncbi.nlm.nih.gov/pubmed/25007067
http://dx.doi.org/10.3390/ijms150712107
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author Wang, Liang
Zhuo, Zhi-Yong
Shi, Wen-Qing
Tan, Dun-Xian
Gao, Chao
Tian, Xiu-Zhi
Zhang, Lu
Zhou, Guang-Bin
Zhu, Shi-En
Yun, Peng
Liu, Guo-Shi
author_facet Wang, Liang
Zhuo, Zhi-Yong
Shi, Wen-Qing
Tan, Dun-Xian
Gao, Chao
Tian, Xiu-Zhi
Zhang, Lu
Zhou, Guang-Bin
Zhu, Shi-En
Yun, Peng
Liu, Guo-Shi
author_sort Wang, Liang
collection PubMed
description In this study, the effects of melatonin (MT) on superovulation and reproductive hormones (melatonin, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and PRL) were investigated in female sika deer. Different doses (40 or 80 mg/animal) of melatonin were subcutaneously implanted into deer before the breeding season. Exogenous melatonin administration significantly elevated the serum FSH levels at the time of insemination compared with levels in control animals. During superovulation, the serum LH levels in donor sika deer reached their highest values (7.1 ± 2.04 ng/mL) at the point of insemination, compared with the baseline levels (4.98 ± 0.07 ng/mL) in control animals. This high level of LH was sustained until the day of embryo recovery. In contrast, the serum levels of PRL in the 80 mg of melatonin-treated group were significantly lower than those of control deer. The average number of corpora lutea in melatonin-treated deer was significantly higher than that of the control (p < 0.05). The average number of embryos in the deer treated with 40 mg of melatonin was higher than that of the control; however, this increase did not reach significant difference (p > 0.05), which may be related to the relatively small sample size. In addition, embryonic development in melatonin-treated groups was delayed.
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spelling pubmed-41398322014-08-21 Melatonin Promotes Superovulation in Sika Deer (Cervus nippon) Wang, Liang Zhuo, Zhi-Yong Shi, Wen-Qing Tan, Dun-Xian Gao, Chao Tian, Xiu-Zhi Zhang, Lu Zhou, Guang-Bin Zhu, Shi-En Yun, Peng Liu, Guo-Shi Int J Mol Sci Article In this study, the effects of melatonin (MT) on superovulation and reproductive hormones (melatonin, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and PRL) were investigated in female sika deer. Different doses (40 or 80 mg/animal) of melatonin were subcutaneously implanted into deer before the breeding season. Exogenous melatonin administration significantly elevated the serum FSH levels at the time of insemination compared with levels in control animals. During superovulation, the serum LH levels in donor sika deer reached their highest values (7.1 ± 2.04 ng/mL) at the point of insemination, compared with the baseline levels (4.98 ± 0.07 ng/mL) in control animals. This high level of LH was sustained until the day of embryo recovery. In contrast, the serum levels of PRL in the 80 mg of melatonin-treated group were significantly lower than those of control deer. The average number of corpora lutea in melatonin-treated deer was significantly higher than that of the control (p < 0.05). The average number of embryos in the deer treated with 40 mg of melatonin was higher than that of the control; however, this increase did not reach significant difference (p > 0.05), which may be related to the relatively small sample size. In addition, embryonic development in melatonin-treated groups was delayed. MDPI 2014-07-08 /pmc/articles/PMC4139832/ /pubmed/25007067 http://dx.doi.org/10.3390/ijms150712107 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wang, Liang
Zhuo, Zhi-Yong
Shi, Wen-Qing
Tan, Dun-Xian
Gao, Chao
Tian, Xiu-Zhi
Zhang, Lu
Zhou, Guang-Bin
Zhu, Shi-En
Yun, Peng
Liu, Guo-Shi
Melatonin Promotes Superovulation in Sika Deer (Cervus nippon)
title Melatonin Promotes Superovulation in Sika Deer (Cervus nippon)
title_full Melatonin Promotes Superovulation in Sika Deer (Cervus nippon)
title_fullStr Melatonin Promotes Superovulation in Sika Deer (Cervus nippon)
title_full_unstemmed Melatonin Promotes Superovulation in Sika Deer (Cervus nippon)
title_short Melatonin Promotes Superovulation in Sika Deer (Cervus nippon)
title_sort melatonin promotes superovulation in sika deer (cervus nippon)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139832/
https://www.ncbi.nlm.nih.gov/pubmed/25007067
http://dx.doi.org/10.3390/ijms150712107
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