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Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model
Hyper-pigmentation causes skin darkness and medical disorders, such as post-inflammatory melanoderma and melasma. Therefore, the development of anti-melanogenic agents is important for treating these conditions and for cosmetic production. In our previous paper, we demonstrated that the anti-diabeti...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139837/ https://www.ncbi.nlm.nih.gov/pubmed/25007819 http://dx.doi.org/10.3390/ijms150712188 |
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author | Bin, Bum-Ho Joo, Yung Hyup Lee, Ai-Young Shin, Song Seok Cho, Eun-Gyung Lee, Tae Ryong |
author_facet | Bin, Bum-Ho Joo, Yung Hyup Lee, Ai-Young Shin, Song Seok Cho, Eun-Gyung Lee, Tae Ryong |
author_sort | Bin, Bum-Ho |
collection | PubMed |
description | Hyper-pigmentation causes skin darkness and medical disorders, such as post-inflammatory melanoderma and melasma. Therefore, the development of anti-melanogenic agents is important for treating these conditions and for cosmetic production. In our previous paper, we demonstrated that the anti-diabetic drug voglibose, a valiolamine derivative, is a potent anti-melanogenic agent. In addition, we proposed an alternative screening strategy to identify valiolamine derivatives with high skin permeability that act as anti-melanogenic agents when applied topically. In this study, we synthesized several valiolamine derivatives with enhanced lipophilicity and examined their inhibitory effects in a human skin model. N-(2-hydroxycyclohexyl)valiolamine (HV) possesses a stronger inhibitory effect on melanin production than voglibose in a human skin model, suggesting that HV is a more potent anti-melanogenic agent for the skin. |
format | Online Article Text |
id | pubmed-4139837 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-41398372014-08-21 Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model Bin, Bum-Ho Joo, Yung Hyup Lee, Ai-Young Shin, Song Seok Cho, Eun-Gyung Lee, Tae Ryong Int J Mol Sci Communication Hyper-pigmentation causes skin darkness and medical disorders, such as post-inflammatory melanoderma and melasma. Therefore, the development of anti-melanogenic agents is important for treating these conditions and for cosmetic production. In our previous paper, we demonstrated that the anti-diabetic drug voglibose, a valiolamine derivative, is a potent anti-melanogenic agent. In addition, we proposed an alternative screening strategy to identify valiolamine derivatives with high skin permeability that act as anti-melanogenic agents when applied topically. In this study, we synthesized several valiolamine derivatives with enhanced lipophilicity and examined their inhibitory effects in a human skin model. N-(2-hydroxycyclohexyl)valiolamine (HV) possesses a stronger inhibitory effect on melanin production than voglibose in a human skin model, suggesting that HV is a more potent anti-melanogenic agent for the skin. MDPI 2014-07-09 /pmc/articles/PMC4139837/ /pubmed/25007819 http://dx.doi.org/10.3390/ijms150712188 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Communication Bin, Bum-Ho Joo, Yung Hyup Lee, Ai-Young Shin, Song Seok Cho, Eun-Gyung Lee, Tae Ryong Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model |
title | Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model |
title_full | Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model |
title_fullStr | Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model |
title_full_unstemmed | Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model |
title_short | Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model |
title_sort | novel inhibitory effect of n-(2-hydroxycyclohexyl)valiolamine on melanin production in a human skin model |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139837/ https://www.ncbi.nlm.nih.gov/pubmed/25007819 http://dx.doi.org/10.3390/ijms150712188 |
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