Cargando…

Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model

Hyper-pigmentation causes skin darkness and medical disorders, such as post-inflammatory melanoderma and melasma. Therefore, the development of anti-melanogenic agents is important for treating these conditions and for cosmetic production. In our previous paper, we demonstrated that the anti-diabeti...

Descripción completa

Detalles Bibliográficos
Autores principales: Bin, Bum-Ho, Joo, Yung Hyup, Lee, Ai-Young, Shin, Song Seok, Cho, Eun-Gyung, Lee, Tae Ryong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139837/
https://www.ncbi.nlm.nih.gov/pubmed/25007819
http://dx.doi.org/10.3390/ijms150712188
_version_ 1782331422640439296
author Bin, Bum-Ho
Joo, Yung Hyup
Lee, Ai-Young
Shin, Song Seok
Cho, Eun-Gyung
Lee, Tae Ryong
author_facet Bin, Bum-Ho
Joo, Yung Hyup
Lee, Ai-Young
Shin, Song Seok
Cho, Eun-Gyung
Lee, Tae Ryong
author_sort Bin, Bum-Ho
collection PubMed
description Hyper-pigmentation causes skin darkness and medical disorders, such as post-inflammatory melanoderma and melasma. Therefore, the development of anti-melanogenic agents is important for treating these conditions and for cosmetic production. In our previous paper, we demonstrated that the anti-diabetic drug voglibose, a valiolamine derivative, is a potent anti-melanogenic agent. In addition, we proposed an alternative screening strategy to identify valiolamine derivatives with high skin permeability that act as anti-melanogenic agents when applied topically. In this study, we synthesized several valiolamine derivatives with enhanced lipophilicity and examined their inhibitory effects in a human skin model. N-(2-hydroxycyclohexyl)valiolamine (HV) possesses a stronger inhibitory effect on melanin production than voglibose in a human skin model, suggesting that HV is a more potent anti-melanogenic agent for the skin.
format Online
Article
Text
id pubmed-4139837
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-41398372014-08-21 Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model Bin, Bum-Ho Joo, Yung Hyup Lee, Ai-Young Shin, Song Seok Cho, Eun-Gyung Lee, Tae Ryong Int J Mol Sci Communication Hyper-pigmentation causes skin darkness and medical disorders, such as post-inflammatory melanoderma and melasma. Therefore, the development of anti-melanogenic agents is important for treating these conditions and for cosmetic production. In our previous paper, we demonstrated that the anti-diabetic drug voglibose, a valiolamine derivative, is a potent anti-melanogenic agent. In addition, we proposed an alternative screening strategy to identify valiolamine derivatives with high skin permeability that act as anti-melanogenic agents when applied topically. In this study, we synthesized several valiolamine derivatives with enhanced lipophilicity and examined their inhibitory effects in a human skin model. N-(2-hydroxycyclohexyl)valiolamine (HV) possesses a stronger inhibitory effect on melanin production than voglibose in a human skin model, suggesting that HV is a more potent anti-melanogenic agent for the skin. MDPI 2014-07-09 /pmc/articles/PMC4139837/ /pubmed/25007819 http://dx.doi.org/10.3390/ijms150712188 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Bin, Bum-Ho
Joo, Yung Hyup
Lee, Ai-Young
Shin, Song Seok
Cho, Eun-Gyung
Lee, Tae Ryong
Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model
title Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model
title_full Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model
title_fullStr Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model
title_full_unstemmed Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model
title_short Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model
title_sort novel inhibitory effect of n-(2-hydroxycyclohexyl)valiolamine on melanin production in a human skin model
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139837/
https://www.ncbi.nlm.nih.gov/pubmed/25007819
http://dx.doi.org/10.3390/ijms150712188
work_keys_str_mv AT binbumho novelinhibitoryeffectofn2hydroxycyclohexylvaliolamineonmelaninproductioninahumanskinmodel
AT jooyunghyup novelinhibitoryeffectofn2hydroxycyclohexylvaliolamineonmelaninproductioninahumanskinmodel
AT leeaiyoung novelinhibitoryeffectofn2hydroxycyclohexylvaliolamineonmelaninproductioninahumanskinmodel
AT shinsongseok novelinhibitoryeffectofn2hydroxycyclohexylvaliolamineonmelaninproductioninahumanskinmodel
AT choeungyung novelinhibitoryeffectofn2hydroxycyclohexylvaliolamineonmelaninproductioninahumanskinmodel
AT leetaeryong novelinhibitoryeffectofn2hydroxycyclohexylvaliolamineonmelaninproductioninahumanskinmodel