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Association of STAT3 Common Variations with Obesity and Hypertriglyceridemia: Protective and Contributive Effects

Signal transducer and activator of transcription 3 (STAT3) plays an important role in energy metabolism. Here we explore whether STAT3 common variations influence risks of obesity and other metabolic disorders in a Chinese Han population. Two tagging single nucleotide polymorphisms (tagSNPs), rs1053...

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Autores principales: Ma, Zuliang, Wang, Guanghai, Chen, Xuejiao, Ou, Zejin, Zou, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139842/
https://www.ncbi.nlm.nih.gov/pubmed/25014397
http://dx.doi.org/10.3390/ijms150712258
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author Ma, Zuliang
Wang, Guanghai
Chen, Xuejiao
Ou, Zejin
Zou, Fei
author_facet Ma, Zuliang
Wang, Guanghai
Chen, Xuejiao
Ou, Zejin
Zou, Fei
author_sort Ma, Zuliang
collection PubMed
description Signal transducer and activator of transcription 3 (STAT3) plays an important role in energy metabolism. Here we explore whether STAT3 common variations influence risks of obesity and other metabolic disorders in a Chinese Han population. Two tagging single nucleotide polymorphisms (tagSNPs), rs1053005 and rs957970, were used to capture the common variations of STAT3. Relationships between genotypes and obesity, body mass index, plasma triglyceride and other metabolic diseases related parameters were analyzed for association study in 1742 subjects. Generalized linear model and logistic regression model were used for quantitative data analysis and case-control study, respectively. rs1053005 was significantly associated with body mass index and waist circumference (p = 0.013 and p = 0.02, respectively). rs957970 was significantly associated with plasma level of triglyceride (p = 0.007). GG genotype at rs1053005 had lower risks of both general obesity and central obesity (OR = 0.40, p = 0.034; OR = 0.42, p = 0.007, respectively) compared with AA genotype. CT genotype at rs957970 had a higher risk of hypertriglyceridemia (OR = 1.43, p = 0.015) compared with TT genotype. Neither of the two SNPs was associated with othermetabolic diseases related parameters. Our observations indicated that common variations of STAT3 could significantly affect the risk of obesity and hypertriglyceridemia in Chinese Han population.
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spelling pubmed-41398422014-08-21 Association of STAT3 Common Variations with Obesity and Hypertriglyceridemia: Protective and Contributive Effects Ma, Zuliang Wang, Guanghai Chen, Xuejiao Ou, Zejin Zou, Fei Int J Mol Sci Article Signal transducer and activator of transcription 3 (STAT3) plays an important role in energy metabolism. Here we explore whether STAT3 common variations influence risks of obesity and other metabolic disorders in a Chinese Han population. Two tagging single nucleotide polymorphisms (tagSNPs), rs1053005 and rs957970, were used to capture the common variations of STAT3. Relationships between genotypes and obesity, body mass index, plasma triglyceride and other metabolic diseases related parameters were analyzed for association study in 1742 subjects. Generalized linear model and logistic regression model were used for quantitative data analysis and case-control study, respectively. rs1053005 was significantly associated with body mass index and waist circumference (p = 0.013 and p = 0.02, respectively). rs957970 was significantly associated with plasma level of triglyceride (p = 0.007). GG genotype at rs1053005 had lower risks of both general obesity and central obesity (OR = 0.40, p = 0.034; OR = 0.42, p = 0.007, respectively) compared with AA genotype. CT genotype at rs957970 had a higher risk of hypertriglyceridemia (OR = 1.43, p = 0.015) compared with TT genotype. Neither of the two SNPs was associated with othermetabolic diseases related parameters. Our observations indicated that common variations of STAT3 could significantly affect the risk of obesity and hypertriglyceridemia in Chinese Han population. MDPI 2014-07-10 /pmc/articles/PMC4139842/ /pubmed/25014397 http://dx.doi.org/10.3390/ijms150712258 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Ma, Zuliang
Wang, Guanghai
Chen, Xuejiao
Ou, Zejin
Zou, Fei
Association of STAT3 Common Variations with Obesity and Hypertriglyceridemia: Protective and Contributive Effects
title Association of STAT3 Common Variations with Obesity and Hypertriglyceridemia: Protective and Contributive Effects
title_full Association of STAT3 Common Variations with Obesity and Hypertriglyceridemia: Protective and Contributive Effects
title_fullStr Association of STAT3 Common Variations with Obesity and Hypertriglyceridemia: Protective and Contributive Effects
title_full_unstemmed Association of STAT3 Common Variations with Obesity and Hypertriglyceridemia: Protective and Contributive Effects
title_short Association of STAT3 Common Variations with Obesity and Hypertriglyceridemia: Protective and Contributive Effects
title_sort association of stat3 common variations with obesity and hypertriglyceridemia: protective and contributive effects
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139842/
https://www.ncbi.nlm.nih.gov/pubmed/25014397
http://dx.doi.org/10.3390/ijms150712258
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