Clinical Significance of POU5F1P1 rs10505477 Polymorphism in Chinese Gastric Cancer Patients Receving Cisplatin-Based Chemotherapy after Surgical Resection

This study aimed to investigate the association between POU class5 homeobox 1 pseudogene 1 gene (POU5F1P1) rs10505477 polymorphism and the prognosis of Chinese gastric cancer patients, who received cisplatin-based chemotherapy after surgical resection. POU5F1P1 rs10505477 was genotyped using the SNa...

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Autores principales: Shen, Lili, Du, Mulong, Wang, Chun, Gu, Dongying, Wang, Meilin, Zhang, Qi, Zhao, Tingting, Zhang, Xunlei, Tan, Yongfei, Huo, Xinying, Gong, Weida, Xu, Zhi, Chen, Jinfei, Zhang, Zhengdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139873/
https://www.ncbi.nlm.nih.gov/pubmed/25046748
http://dx.doi.org/10.3390/ijms150712764
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author Shen, Lili
Du, Mulong
Wang, Chun
Gu, Dongying
Wang, Meilin
Zhang, Qi
Zhao, Tingting
Zhang, Xunlei
Tan, Yongfei
Huo, Xinying
Gong, Weida
Xu, Zhi
Chen, Jinfei
Zhang, Zhengdong
author_facet Shen, Lili
Du, Mulong
Wang, Chun
Gu, Dongying
Wang, Meilin
Zhang, Qi
Zhao, Tingting
Zhang, Xunlei
Tan, Yongfei
Huo, Xinying
Gong, Weida
Xu, Zhi
Chen, Jinfei
Zhang, Zhengdong
author_sort Shen, Lili
collection PubMed
description This study aimed to investigate the association between POU class5 homeobox 1 pseudogene 1 gene (POU5F1P1) rs10505477 polymorphism and the prognosis of Chinese gastric cancer patients, who received cisplatin-based chemotherapy after surgical resection. POU5F1P1 rs10505477 was genotyped using the SNaPshot method in 944 gastric cancer patients who received gastrectomy. The association of rs10505477 G > A polymorphism with the progression and prognosis in gastric cancer patients was statistically analyzed using the SPSS version 18.0 for Windows. The results reveal that rs10505477 polymorphism has a negatively effect on the overall survival of gastric cancer patients in cisplatin-based chemotherapy subgroup (HR = 1.764, 95% CI = 1.069–2.911, p = 0.023). Our preliminary study indicates for the first time that POU5F1P1 rs10505477 is correlated with survival of gastric cancer patients who receving cisplatin-based chemotherapy after gastrectomy. Further studies are warranted to investigate the mechanism and to verify our results in different populations.
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spelling pubmed-41398732014-08-21 Clinical Significance of POU5F1P1 rs10505477 Polymorphism in Chinese Gastric Cancer Patients Receving Cisplatin-Based Chemotherapy after Surgical Resection Shen, Lili Du, Mulong Wang, Chun Gu, Dongying Wang, Meilin Zhang, Qi Zhao, Tingting Zhang, Xunlei Tan, Yongfei Huo, Xinying Gong, Weida Xu, Zhi Chen, Jinfei Zhang, Zhengdong Int J Mol Sci Article This study aimed to investigate the association between POU class5 homeobox 1 pseudogene 1 gene (POU5F1P1) rs10505477 polymorphism and the prognosis of Chinese gastric cancer patients, who received cisplatin-based chemotherapy after surgical resection. POU5F1P1 rs10505477 was genotyped using the SNaPshot method in 944 gastric cancer patients who received gastrectomy. The association of rs10505477 G > A polymorphism with the progression and prognosis in gastric cancer patients was statistically analyzed using the SPSS version 18.0 for Windows. The results reveal that rs10505477 polymorphism has a negatively effect on the overall survival of gastric cancer patients in cisplatin-based chemotherapy subgroup (HR = 1.764, 95% CI = 1.069–2.911, p = 0.023). Our preliminary study indicates for the first time that POU5F1P1 rs10505477 is correlated with survival of gastric cancer patients who receving cisplatin-based chemotherapy after gastrectomy. Further studies are warranted to investigate the mechanism and to verify our results in different populations. MDPI 2014-07-18 /pmc/articles/PMC4139873/ /pubmed/25046748 http://dx.doi.org/10.3390/ijms150712764 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Shen, Lili
Du, Mulong
Wang, Chun
Gu, Dongying
Wang, Meilin
Zhang, Qi
Zhao, Tingting
Zhang, Xunlei
Tan, Yongfei
Huo, Xinying
Gong, Weida
Xu, Zhi
Chen, Jinfei
Zhang, Zhengdong
Clinical Significance of POU5F1P1 rs10505477 Polymorphism in Chinese Gastric Cancer Patients Receving Cisplatin-Based Chemotherapy after Surgical Resection
title Clinical Significance of POU5F1P1 rs10505477 Polymorphism in Chinese Gastric Cancer Patients Receving Cisplatin-Based Chemotherapy after Surgical Resection
title_full Clinical Significance of POU5F1P1 rs10505477 Polymorphism in Chinese Gastric Cancer Patients Receving Cisplatin-Based Chemotherapy after Surgical Resection
title_fullStr Clinical Significance of POU5F1P1 rs10505477 Polymorphism in Chinese Gastric Cancer Patients Receving Cisplatin-Based Chemotherapy after Surgical Resection
title_full_unstemmed Clinical Significance of POU5F1P1 rs10505477 Polymorphism in Chinese Gastric Cancer Patients Receving Cisplatin-Based Chemotherapy after Surgical Resection
title_short Clinical Significance of POU5F1P1 rs10505477 Polymorphism in Chinese Gastric Cancer Patients Receving Cisplatin-Based Chemotherapy after Surgical Resection
title_sort clinical significance of pou5f1p1 rs10505477 polymorphism in chinese gastric cancer patients receving cisplatin-based chemotherapy after surgical resection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139873/
https://www.ncbi.nlm.nih.gov/pubmed/25046748
http://dx.doi.org/10.3390/ijms150712764
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